Aging‐related cell type‐specific pathophysiologic immune responses that exacerbate disease severity in aged COVID‐19 patients

Aging Cell

Timothy A. Chan¹  Yuan Luo²  Michaela U. Gack³  Yuan Hou⁴  Yadi Zhou⁴  Feixiong Cheng⁵  Charis Eng⁶  Andrew A. Pieper⁷  Lara Jehi⁸  Haiyuan Yu⁹ 

[1] Center for Immunotherapy and Precision Immuno‐Oncology, Cleveland Clinic, Cleveland, Ohio, USA;Division of Health and Biomedical Informatics, Department of Preventive Medicine, Clinical and Translational Sciences Institute and Center for Health Information Partnerships, Northwestern University, Evanston, Illinois, USA;Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, Florida, USA;Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA;Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA;Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA;Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA;Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA;Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA;Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA;Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA;Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA;Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA;Geriatric Psychiatry, GRECC, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA;Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA;Weill Cornell Autism Research Program, Weill Cornell Medicine of Cornell University, New York, New York, USA;Department of Neuroscience, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA;Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA;Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA;Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, USA;Department of Computational Biology, Cornell University, Ithaca, New York, USA;

关键词: aging;    cellular immunology;    COVID‐19;    molecular biology of aging;    SARS‐CoV‐2;   

DOI  :  10.1111/acel.13544

来源: Wiley

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CC BY