Guaiacol suppresses osteoclastogenesis by blocking interactions of RANK with TRAF6 and C‐Src and inhibiting NF‐κB, MAPK and AKT pathways

Journal of Cellular and Molecular Medicine

Yajun Wang¹  Jin Cui¹  Hao Jiang¹  Weizong Weng¹  Qirong Zhou¹  Chao Fang¹  Huiwen Chen¹  Yan Hu¹  Yao Wang¹  Xin Zhi²  Xiaoqun Li²  Jiacan Su³  Xiao Chen⁴  Liehu Cao⁵  Yanqiu Gu⁶  Xiaofei Chen⁷ 

[1] Department of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Military Medical University, Shanghai, China;Department of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Military Medical University, Shanghai, China;Basic Medical School, Naval Military Medical University, Shanghai, China;Department of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Military Medical University, Shanghai, China;China‐South Korea Bioengineering Center, Shanghai, China;Department of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Military Medical University, Shanghai, China;Department of Chemistry, Fudan University, Shanghai, China;Department of Orthopedics Trauma, Shanghai Luodian Hospital, Shanghai, China;Department of Pharmacy, Shanghai 9th People’s Hospital, Shanghai, China;School of Pharmacy, Naval Military Medical University, Shanghai, China;

关键词: guaiacol;    osteoclastogenesis;    osteoporosis;    rankl;   

DOI  :  10.1111/jcmm.15153

来源: Wiley

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