Genome‐scale metabolic modeling reveals SARS‐CoV‐2‐induced metabolic changes and antiviral targets

Molecular Systems Biology

Nishanth Ulhas Nair¹  Lipika R Pal¹  Kuoyuan Cheng²  Sanju Sinha²  Eytan Ruppin³  Sumit K Chanda⁴  Yuan Pu⁴  Laura Riva⁴  Laura Martin‐Sancho⁴  Xin Yin⁵ 

[1] Cancer Data Science Laboratory (CDSL), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA;Cancer Data Science Laboratory (CDSL), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA;Biological Sciences Graduate Program (BISI), University of Maryland, College Park, MD, USA;Cancer Data Science Laboratory (CDSL), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA;Department of Computer Science, University of Maryland, College Park, MD, USA;Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA;Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA;State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China;

关键词: antiviral target;    genome‐scale metabolic modeling;    remdesivir;    RNAi screen;    SARS‐CoV‐2;   

DOI  :  10.15252/msb.202110260

来源: Wiley

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