Most primary olfactory neurons have individually neutral effects on behavior

eLife

Safwan Burhanudin¹  James Stewart¹  Asghar Khalilnezhad¹  Hyungwon Choi²  Tayfun Tumkaya³  Adam Claridge-Chang⁴ 

[1] Institute for Molecular and Cell Biology, A*STAR, Singapore, Singapore;Institute for Molecular and Cell Biology, A*STAR, Singapore, Singapore;Department of Medicine, National University of Singapore, Singapore, Singapore;Institute for Molecular and Cell Biology, A*STAR, Singapore, Singapore;Program in Neuroscience and Behavioral Disorders, Duke NUS Graduate Medical School, Singapore, Singapore;Institute for Molecular and Cell Biology, A*STAR, Singapore, Singapore;Program in Neuroscience and Behavioral Disorders, Duke NUS Graduate Medical School, Singapore, Singapore;Department of Physiology, National University of Singapore, Singapore, Singapore;

关键词: olfaction;    olfactory receptor neuron;    valence;    odor;    behavior;    optogenetics;    D. melanogaster;   

DOI  :  10.7554/eLife.71238

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Animals use olfactory receptors to navigate mates, food, and danger. However, for complex olfactory systems, it is unknown what proportion of primary olfactory sensory neurons can individually drive avoidance or attraction. Similarly, the rules that govern behavioral responses to receptor combinations are unclear. We used optogenetic analysis in Drosophila to map the behavior elicited by olfactory-receptor neuron (ORN) classes: just one-fifth of ORN-types drove either avoidance or attraction. Although wind and hunger are closely linked to olfaction, neither had much effect on single-class responses. Several pooling rules have been invoked to explain how ORN types combine their behavioral influences; we activated two-way combinations and compared patterns of single- and double-ORN responses: these comparisons were inconsistent with simple pooling. We infer that the majority of primary olfactory sensory neurons have neutral behavioral effects individually, but participate in broad, odor-elicited ensembles with potent behavioral effects arising from complex interactions.

【 授权许可】

CC BY