Effects of Cognitive Behavioral Therapy on Pain and Sleep in Adults with Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Neural Plasticity

Hong Wang¹  Peiyuan Ding²  Jianping Xia³  Xuan Zhou⁴  Qimeng Fan⁴  Qing Du⁴  Zhengquan Chen⁴  Yuwei Feng⁴  Nan Chen⁵  Xin Li⁶ 

[1] College of Rehabilitation Science, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China, sumhs.edu.cn;Department of Neurosurgery, Chongming Branch of Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 202150, China, sjtu.edu.cn;Department of Rehabilitation, Maternity & Child Care Center of Xinyu, Xinyu, 338000 Jiangxi, China;Department of Rehabilitation, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China, sjtu.edu.cn;Department of Rehabilitation, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China, sjtu.edu.cn;Department of Rehabilitation, Chongming Branch of Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 202150, China, sjtu.edu.cn;Department of Rehabilitation, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China, sjtu.edu.cn;School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China, sus.edu.cn;

DOI  :  10.1155/2021/6552246

来源: Hindawi Publishing Corporation

【 摘 要 】

The objective of this study was to systematically review the literature on the effects of cognitive behavioral therapy (CBT) on insomnia and pain in patients with traumatic brain injury (TBI). PubMed, Embase, the Cochrane Library, Cumulative Index to Nursing and Allied Health, and Web of Science databases were searched. Outcomes, including pain, sleep quality, and adverse events, were investigated. Differences were expressed using mean differences (MDs) with 95% confidence intervals (CIs). The statistical analysis was performed using STATA 16.0. Twelve trials with 476 TBI patients were included. The included studies did not indicate a positive effect of CBT on pain. Significant improvements were shown for self-reported sleep quality, reported with the Pittsburgh Self-Reported Sleep Quality Index (MD, -2.30; 95% CI, -3.45 to -1.15; P<0.001) and Insomnia Severity Index (MD, -5.12; 95% CI, -9.69 to -0.55; P=0.028). No major adverse events related to CBT were reported. The underpowered evidence suggested that CBT is effective in the management of sleep quality and pain in TBI adults. Future studies with larger samples are recommended to determine significance. This trial is registered with PROSPERO registration number CRD42019147266.

【 授权许可】

CC BY