期刊论文详细信息
eLife
Light sets the brain’s daily clock by regional quickening and slowing of the molecular clockworks at dawn and dusk
Suil Kim1  Douglas G McMahon2 
[1] Vanderbilt Brain Institute, Vanderbilt University, Nashville, United States;Vanderbilt Brain Institute, Vanderbilt University, Nashville, United States;Department of Biological Sciences, Vanderbilt University, Nashville, United States;
关键词: circadian rhythm;    entrainment;    SCN;    phase shift;    circadian clock;    photoperiod;    Mouse;   
DOI  :  10.7554/eLife.70137
来源: eLife Sciences Publications, Ltd
PDF
【 摘 要 】

How daily clocks in the brain are set by light to local environmental time and encode the seasons is not fully understood. The suprachiasmatic nucleus (SCN) is a central circadian clock in mammals that orchestrates physiology and behavior in tune with daily and seasonal light cycles. Here, we have found that optogenetically simulated light input to explanted mouse SCN changes the waveform of the molecular clockworks from sinusoids in free-running conditions to highly asymmetrical shapes with accelerated synthetic (rising) phases and extended degradative (falling) phases marking clock advances and delays at simulated dawn and dusk. Daily waveform changes arise under ex vivo entrainment to simulated winter and summer photoperiods, and to non-24 hr periods. Ex vivo SCN imaging further suggests that acute waveform shifts are greatest in the ventrolateral SCN, while period effects are greatest in the dorsomedial SCN. Thus, circadian entrainment is encoded by SCN clock gene waveform changes that arise from spatiotemporally distinct intrinsic responses within the SCN neural network.

【 授权许可】

CC BY   

【 预 览 】
附件列表
Files Size Format View
RO202112118902082ZK.pdf 5459KB PDF download
  文献评价指标  
  下载次数:10次 浏览次数:3次