eLife | |
Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum | |
Kenji Sakimura1  Manabu Abe1  Chi Chung Alan Fung2  Tomoki Fukai2  Sunita Ghimire Gautam3  Yukiko Goda3  Angelo Tedoldi3  Peter H Chipman3  Abhilash Sawant3  Alejandra Pazo Fernandez3  Mizuki Kurosawa3  Atsushi Kawai3  | |
[1] Department of Animal Model Development, Brain Research Institute, Niigata University, Niigata, Japan;Neural Coding and Brain Computing Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Japan;RIKEN Center for Brain Science, Wako-shi, Saitama, Japan; | |
关键词: basal synaptic strength; hippocampus; astrocytes; NMDA receptors; GluN2C; stratum radiatum; Mouse; | |
DOI : 10.7554/eLife.70818 | |
来源: eLife Sciences Publications, Ltd | |
【 摘 要 】
Experience-dependent plasticity is a key feature of brain synapses for which neuronal N-Methyl-D-Aspartate receptors (NMDARs) play a major role, from developmental circuit refinement to learning and memory. Astrocytes also express NMDARs, although their exact function has remained controversial. Here, we identify in mouse hippocampus, a circuit function for GluN2C NMDAR, a subtype highly expressed in astrocytes, in layer-specific tuning of synaptic strengths in CA1 pyramidal neurons. Interfering with astrocyte NMDAR or GluN2C NMDAR activity reduces the range of presynaptic strength distribution specifically in the stratum radiatum inputs without an appreciable change in the mean presynaptic strength. Mathematical modeling shows that narrowing of the width of presynaptic release probability distribution compromises the expression of long-term synaptic plasticity. Our findings suggest a novel feedback signaling system that uses astrocyte GluN2C NMDARs to adjust basal synaptic weight distribution of Schaffer collateral inputs, which in turn impacts computations performed by the CA1 pyramidal neuron.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202112118537388ZK.pdf | 4757KB | download |