Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality

eLife

Chen Wu¹  Joseph C Madara¹  Angela Kim²  Mark L Andermann²  Bradford B Lowell² 

[1] Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States;Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States;Program in Neuroscience, Harvard Medical School, Boston, United States;

关键词: vasopressin;    presystemic;    feedforward;    osmolality;    water balance;    fiber photometry;    Mouse;   

DOI  :  10.7554/eLife.66609

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Water balance, tracked by extracellular osmolality, is regulated by feedback and feedforward mechanisms. Feedback regulation is reactive, occurring as deviations in osmolality are detected. Feedforward or presystemic regulation is proactive, occurring when disturbances in osmolality are anticipated. Vasopressin (AVP) is a key hormone regulating water balance and is released during hyperosmolality to limit renal water excretion. AVP neurons are under feedback and feedforward regulation. Not only do they respond to disturbances in blood osmolality, but they are also rapidly suppressed and stimulated, respectively, by drinking and eating, which will ultimately decrease and increase osmolality. Here, we demonstrate that AVP neuron activity is regulated by multiple anatomically and functionally distinct neural circuits. Notably, presystemic regulation during drinking and eating are mediated by non-overlapping circuits that involve the lamina terminalis and hypothalamic arcuate nucleus, respectively. These findings reveal neural mechanisms that support differential regulation of AVP release by diverse behavioral and physiological stimuli.

【 授权许可】

CC BY