Control of parallel hippocampal output pathways by amygdalar long-range inhibition

eLife

Ryan WS Wee¹  Rawan AlSubaie¹  Jessica Passlack¹  Anne Ritoux¹  Karyna Mishchanchuk¹  Daniel Regester¹  Andrew F MacAskill¹ 

[1] Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom;

关键词: hippocampus;    amygdala;    prefrontal cortex;    nucleus accumbens;    reward;    inhibition;    Mouse;   

DOI  :  10.7554/eLife.74758

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Projections from the basal amygdala (BA) to the ventral hippocampus (vH) are proposed to provide information about the rewarding or threatening nature of learned associations to support appropriate goal-directed and anxiety-like behaviour. Such behaviour occurs via the differential activity of multiple, parallel populations of pyramidal neurons in vH that project to distinct downstream targets, but the nature of BA input and how it connects with these populations is unclear. Using channelrhodopsin-2-assisted circuit mapping in mice, we show that BA input to vH consists of both excitatory and inhibitory projections. Excitatory input specifically targets BA- and nucleus accumbens-projecting vH neurons and avoids prefrontal cortex-projecting vH neurons, while inhibitory input preferentially targets BA-projecting neurons. Through this specific connectivity, BA inhibitory projections gate place-value associations by controlling the activity of nucleus accumbens-projecting vH neurons. Our results define a parallel excitatory and inhibitory projection from BA to vH that can support goal-directed behaviour.

【 授权许可】

CC BY