The role of ceRNA-mediated diagnosis and therapy in hepatocellular carcinoma

Hereditas

Ji-Bin Liu¹  Yu-Shui Ma¹  Fu Da²  Yi Shi³  Wen Li⁴  Jie Yin⁵  Ya-Hong Cao⁶  Da-Zhi Zou⁷  Jian-Jun Wu⁸  Jing Deng⁹ 

[1] Cancer Institute, Affiliated Tumor Hospital of Nantong University, 226631, Nantong, China;Cancer Institute, Affiliated Tumor Hospital of Nantong University, 226631, Nantong, China;National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, 410004, Changsha, Hunan, China;College of Life Sciences and Chemistry, Hunan University of Technology, 412007, Zhuzhou, Hunan, China;Cancer Institute, Affiliated Tumor Hospital of Nantong University, 226631, Nantong, China;National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, 410004, Changsha, Hunan, China;College of Life Sciences and Chemistry, Hunan University of Technology, 412007, Zhuzhou, Hunan, China;National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, 410004, Changsha, Hunan, China;Department of General Surgery, Haian people’s Hospital, 226600, Haian, Jiangsu, China;Department of Respiratory, Nantong Traditional Chinese Medicine Hospital, 226019, Nantong, Jiangsu Province, China;Department of Spine Surgery, Longhui County People’s Hospital, 422200, Longhui, Hunan, China;Nantong Haimen Yuelai Health Centre, 226100, Haimen, China;National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, 410004, Changsha, Hunan, China;

关键词: Epidemiology;    HCC;    ceRNA;    ceRNET;    Mechanism;    Function;   

DOI  :  10.1186/s41065-021-00208-7

来源: Springer

【 摘 要 】

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide due to its high degree of malignancy, high incidence, and low survival rate. However, the underlying mechanisms of hepatocarcinogenesis remain unclear. Long non coding RNA (lncRNA) has been shown as a novel type of RNA. lncRNA by acting as ceRNA can participate in various biological processes of HCC cells, such as tumor cell proliferation, migration, invasion, apoptosis and drug resistance by regulating downstream target gene expression and cancer-related signaling pathways. Meanwhile, lncRNA can predict the efficacy of treatment strategies for HCC and serve as a potential target for the diagnosis and treatment of HCC. Therefore, lncRNA serving as ceRNA may become a vital candidate biomarker for clinical diagnosis and treatment. In this review, the epidemiology of HCC, including morbidity, mortality, regional distribution, risk factors, and current treatment advances, was briefly discussed, and some biological functions of lncRNA in HCC were summarized with emphasis on the molecular mechanism and clinical application of lncRNA-mediated ceRNA regulatory network in HCC. This paper can contribute to the better understanding of the mechanism of the influence of lncRNA-mediated ceRNA networks (ceRNETs) on HCC and provide directions and strategies for future studies.

【 授权许可】

CC BY