The effect of opioid-free anesthesia protocol on the early quality of recovery after major surgery (SOFA trial): study protocol for a prospective, monocentric, randomized, single-blinded trial

Trials

Elsa Parot-Schinkel¹  Emmanuel Rineau²  Fabienne Costerousse²  Sigismond Lasocki²  Tristan Perrault²  Solène Pessiot-Royer²  Maxime Léger³ 

[1] Centre Hospitalier Universitaire d’Angers, Département de Biostatistiques et Méthodologie, Angers, France;Département d’Anesthésie Réanimation, Centre Hospitalier Universitaire d’Angers, Angers, France;Département d’Anesthésie Réanimation, Centre Hospitalier Universitaire d’Angers, Angers, France;INSERM UMR 1246 - SPHERE, Nantes University, Tours University, Nantes, France;

关键词: Anesthesia;    Opioid-free anesthesia;    Opioid-related adverse effects;    Quality of recovery;    Quality of life;    Perioperative care;    Patient-reported outcome measures;   

DOI  :  10.1186/s13063-021-05829-x

来源: Springer

【 摘 要 】

BackgroundSince the 2000s, opioid-free anesthesia (OFA) protocols have been spreading worldwide in anesthesia daily practice. These protocols avoid using opioid drugs during anesthesia to prevent short- and long-term opioid side effects while ensuring adequate analgesic control and optimizing postoperative recovery. Proofs of the effect of OFA protocol on optimizing postoperative recovery are still scarce. The study aims to compare the effects of an OFA protocol versus standard anesthesia protocol on the early quality of postoperative recovery (QoR) from major surgeries.MethodsThe SOFA trial is a prospective, randomized, parallel, single-blind, monocentric study. Patients (n = 140) scheduled for major plastic, visceral, urologic, gynecologic, or ear, nose, and throat (ENT) surgeries will be allocated to one of the two groups. The study group (OFA group) will receive a combination of clonidine, magnesium sulfate, ketamine, and lidocaine. The control group will receive a standard anesthesia protocol based on opioid use. Both groups will receive others standard practices for general anesthesia and perioperative care. The primary outcome measure is the QoR-15 value assessed at 24 h after surgery. Postoperative data such as pain intensity, the incidence of postoperative complication, and opioid consumption will be recorded. We will also collect adverse events that may be related to the anesthetic protocol. Three months after surgery, the incidence of chronic pain and the quality of life will be evaluated by phone interview.DiscussionThis will be the first study powered to evaluate the effect of OFA versus a standard anesthesia protocol using opioids on global postoperative recovery after a wide range of major surgeries. The SOFA trial will also provide findings concerning the OFA impact on chronic pain incidence and long-term patient quality of life.Trial registrationClinicalTrials.gov NCT04797312. Registered on 15 March 2021

【 授权许可】

CC BY