Metacognitive therapy and work-focused interventions for patients on sick leave due to anxiety and depression: study protocol for a randomised controlled wait-list trial

Trials

Silje Endresen Reme¹  Marit Hannisdal²  Kåre Osnes²  Jonas S. R. Leversen²  Lars G. Røv²  Torkil Berge²  Ragne G. H. Gjengedal³  Odin Hjemdal³  Kenneth Sandin³  Gemma Shields⁴  Adrian Wells⁵  Suzanne Lagerveld⁶  Hans M. Nordahl⁷  Roland Blonk⁸ 

[1] Department of Psychology, Faculty of Social Sciences, University of Oslo, Oslo, Norway;Division of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Postboks 23 Vinderen, 0319, Oslo, Norway;Division of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Postboks 23 Vinderen, 0319, Oslo, Norway;Department of Psychology, Norwegian University of Science and Technology, NO-7491, Trondheim, Norway;Division of Population Health, Health Services Research, and Primary Care, University of Manchester, Manchester, UK;Division of Population Health, Health Services Research, and Primary Care, University of Manchester, Manchester, UK;Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK;Dutch Institute for Employee Benefit Schemes (UWV), Amsterdam, The Netherlands;Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway;TNO Leiden, Leiden, The Netherlands;

关键词: Sick leave;    Anxiety;    Depression;    Work-focused interventions;    Metacognitive therapy;    Cost-effectiveness;    Randomised controlled trial;   

DOI  :  10.1186/s13063-021-05822-4

来源: Springer

【 摘 要 】

BackgroundCommon mental disorders such as depression and anxiety are major contributors to the global burden of disease. Affected individuals suffer reduced quality of life, impaired functioning and reduced capacity to work. Maintaining employment is an important determinant for health and wellbeing, and the economic impact of depression and anxiety is a significant societal expense. Treatments providing effective symptom reduction and helping patients return to work (RTW) would thus have substantial public health benefits. The present study will explore the effectiveness of metacognitive therapy (MCT) and work-focused interventions on reducing symptoms and increasing RTW rates for patients on sick leave due to depression and anxiety.MethodsThe study is a randomised controlled wait-list trial (RCT; N = 240). The intervention group will receive protocol-based MCT and work-focused interventions immediately after inclusion. The control condition is a wait-list control group. All patients will receive up to 12 weekly sessions. The study context is a Norwegian outpatient clinic part of a national programme aimed at reducing sick leave. The co-primary outcomes are change in RTW and symptoms of depression and anxiety at the end of treatment. In addition to self-report, sick leave will also be collected from national registries from 2 years prior to intervention to 4 years after intervention. Symptoms of scores will be collected by self-report at pre- and post-treatment and at 6 and 12 months follow-up after treatment. A cost-effectiveness analysis will use total cost and quality-adjusted life-years as the secondary outcomes.DiscussionThere is broad consensus on the importance of identifying treatment that effectively reduces depression and anxiety symptoms and aids RTW. This study is an important contribution to the field as it is the first RCT on MCT and work-focused interventions for patients on sick leave due to anxiety and depression.Trial registrationClinicalTrials.gov NCT03301922. Registered on October 4, 2017.

【 授权许可】

CC BY