Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial

BMC Nutrition

Magne Thoresen¹  Siv K. Bøhn²  Iris Erlund³  Mari C. W. Myhrstad⁴  Nasser E. Bastani⁵  Rune Blomhoff⁵  Monica H. Carlsen⁵  Ann Kristin Vasstrand⁶  Kjell M. Flekkøy⁶  Anne Marciuch⁶  Knut Engedal⁷ 

[1] Department of Biostatistics, Institute of Basic Medical Sciences, Oslo, Norway;Department of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life Sciences, Ås, Norway;Department of Government Services, Finnish Institute for Health and Welfare, Helsinki, Finland;Department of Nutrition, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway;Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway;Department of Psychology, University of Oslo, Oslo, Norway;Department of geriatric medicine, Oslo university hospital, Oslo, Norway;

关键词: Bilberry;    blueberry;    blueberries;    Grape;    Cytokines;    Memory;    Inflammation;    Aged men;   

DOI  :  10.1186/s40795-021-00482-8

来源: Springer

【 摘 要 】

BackgroundFew randomized clinical trials have explored the health effects of bilberries in humans. The aim was to test the effect of bilberry and red grape-juice consumption on visual memory, motor speed and dexterity as well as inflammatory and tissue damage biomarkers of plasma in aged men with subjective memory impairment.MethodsNine-week double-blind, placebo-controlled, dietary intervention study of aged men (n = 60, age ≥ 67 years) with subjective memory impairment randomized to consume a 50/50 mix of bilberry/red grape-juice or an iso-caloric placebo juice. A selection of Cambridge Cognition Test Battery (CANTAB), Grooved Pegboard tests and blood-sampling for biomarker analysis were performed before and after the intervention.ResultsCompared to placebo the selected memory and motor test scores were un-affected by the bilberry/red grape intervention. However, the plasma levels of tissue damage biomarkers decreased significantly more in the bilberry/red grape group. In particular lactate dehydrogenase (LDH) decreased from 362 U/L (median, baseline) to 346 U/L (median, post intervention) in the bilberry/red grape group. Also, several biomarkers of inflammation (EGF, IL6, IL9, IL10 and TNFα) decreased significantly more in the bilberry/red grape group. Furthermore, several plasma polyphenols; p-coumaric acid, hippuric acid, protocatechuic acid, 3HPAA and vanillic acid, increased significantly more in the bilberry/red grape group compared to placebo with the largest increase in p-coumaric acid with 116%; from 2.2 [1.0,5.5] to 4.7 [2.8,8.1] μM/L (median [95% CL]).ConclusionsThe results indicate that a nine-week bilberry/red grape juice intervention has no measurable effects on the selected memory scores in aged men experiencing memory problems but decreases the level of biomarkers of inflammation and tissue damage. Whether the dampening effects on inflammation and tissue damage biomarkers have relevance for neuroinflammatory brain pathology remains to be established.Trial registrationRegistration number (ClinicalTrials.gov: NCT00972972), September 9, 2009.

【 授权许可】

CC BY