Randomized, double-blind, placebo-controlled clinical trial measuring the effect of a dietetic food on dermatologic scoring and pruritus in dogs with atopic dermatitis

BMC Veterinary Research

José Luis González Arribas¹  Miguel Sánchez de Santiago¹  Yolanda Moral Llamas¹  Iveta Becvarova²  Hein Meyer² 

[1] Clinical Veterinary Hospital, Complutense University, Puerta de Hierro s/n, 28040, Madrid, Spain;Hill’s Pet Nutrition Inc., 400 Southwest Eighth Avenue, 66603, Topeka, KS, USA;

关键词: Canine;    Atopy;    Nutrition;    Allergy;    Dermatology;    Veterinary;    Diet;   

DOI  :  10.1186/s12917-021-03063-w

来源: Springer

【 摘 要 】

BackgroundCanine atopic dermatitis (AD) is a common condition that often requires multimodal therapy. Including a diet in the multimodal management of AD may reduce medication doses, saving pet owners money and reducing side effects. The objective of this randomized, double-blind, placebo-controlled clinical trial was to determine if a diet fortified in antioxidants, polyphenols, and omega-3 fatty acids can reduce the clinical signs of AD. Forty client-owned dogs with AD were enrolled in the study and assigned to either an enriched diet (diet B) or control diet (diet A) for 60-days. CADESI-4 index scores and owner-reported pruritus scores were measured periodically.ResultsTotal CADESI-4 index scores for dogs eating diet B were lower on day 60 compared to baseline (P = 0.003). There was no statistical difference in scores for dogs eating diet A over a 60-day period. Diet B dogs had 25 and 49% reductions in CADESI-4 index scores on days 30 and 60, respectively (P = 0.0007) while diet A had no change over the study period. When comparing the percent change in owner-reported pruritus scores, diet B also performed better than diet A. By day 60, owners feeding diet B to their dogs reported a significant reduction (P < 0.0001) of 46.4% in itching, while those on diet A reported a 26.8% reduction, which was not statistically significant (P = 0.08).ConclusionsThese study results demonstrate feeding a diet enriched with ingredients to improve skin health and reduce inflammation improves the clinical signs of AD in dogs.

【 授权许可】

CC BY