The course of bipolar disorder in pregnant versus non-pregnant women

International Journal of Bipolar Disorders

Adriaan Honig¹  Birit F. P. Broekman¹  Stasja Draisma²  R. W. Kupka³  Robert M. Post⁴  Anja W. M. M. Stevens⁵  Peter J. J. Goossens⁶  Willem A. Nolen⁷  Elise A. M. Knoppert-van der Klein⁸ 

[1] Amsterdam UMC, Vrije Universiteit, Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands;Department of Psychiatry, OLVG Hospital, Amsterdam, The Netherlands;Amsterdam UMC, Vrije Universiteit, Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands;GGZinGeest Specialized Mental Health Care, Research and Innovation Amsterdam, Amsterdam, The Netherlands;Amsterdam UMC, Vrije Universiteit, Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands;GGZinGeest Specialized Mental Health Care, Research and Innovation Amsterdam, Amsterdam, The Netherlands;Bipolar Collaborative Network, Bethesda, MD, USA;Bipolar Collaborative Network, Bethesda, MD, USA;Department of Psychiatry and Behavioral Sciences, District of Columbia, George Washington University, Washington, USA;Center for Bipolar Disorders, Dimence Mental Health, Deventer, The Netherlands;Amsterdam UMC, Vrije Universiteit, Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands;Center for Bipolar Disorders, Dimence Mental Health, Deventer, The Netherlands;Department of Public Health, Faculty of Medicine and Health Sciences, University Centre for Nursing and Midwifery, Ghent University, Ghent, Belgium;Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;Bipolar Collaborative Network, Bethesda, MD, USA;GGZ Rivierduinen Alphen a/d Rijn, Amsterdam, The Netherlands;

关键词: Bipolar disorder;    Course;    Pregnancy;    Life chart method;   

DOI  :  10.1186/s40345-021-00239-z

来源: Springer

【 摘 要 】

Background and rationaleAlthough it has been suggested that pregnancy may influence the course of bipolar disorder (BD), studies show contradictory results. Until now, no studies included a finegrained validated method to report mood symptoms on a daily basis, such as the lifechart method (LCM). The aim of the present study is to investigate the course of BD during pregnancy by comparing LCM scores of pregnant and non-pregnant women.MethodsStudy design: Comparison of LCM scores of two prospective observational BD cohort studies, a cohort of pregnant women (n = 34) and a cohort of non-pregnant women of childbearing age (n = 52). Main study parameters are: (1) proportions of symptomatic and non-symptomatic days; (2) symptom severity, frequency, and duration of episodes; (3) state sequences, longitudinal variation of symptom severity scores.ResultsNo differences in clinical course variables (symptomatic days, average severity scores, frequency, and duration of episodes in BD were found between pregnant and non-pregnant women. With a combination of State Sequence Analysis (SSA) and cluster analysis on the sequences of daily mood scores three comparable clusters were found in both samples: euthymic, moderately ill and severely ill. The distribution differences between pregnant and non-pregnant women were significant, with a majority of the pregnant women (68%) belonging to the moderately ill cluster and a majority of the non-pregnant women (46%) to the euthymic cluster. In pregnant women the average daily variation in mood symptoms as assessed with Shannon’s entropy was less than in non-pregnant women (respectively 0.43 versus 0.56).ConclusionsAlthough the use of daily mood scores revealed no difference in overall course of BD in pregnant versus non-pregnant women, more pregnant than non-pregnant women belonged to the moderately ill cluster, and during pregnancy the variation in mood state was less than in non-pregnant women. Further research is necessary to clarify these findings.

【 授权许可】

CC BY