Changes of cerebral cortical structure and cognitive dysfunction in “healthy hemisphere” after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease

BMC Neuroscience

Cai Zhang¹  Tian Li¹  Ning Ma²  Ziqi Liu²  Shihao He²  Yanchang Wei²  Xiaoyuan Liu²  Rong Wang³  Ran Duan⁴  Xin Lou⁵ 

[1] Collaborative Innovation Center of Assessment for Basic Education Quality, Beijing Normal University, 100875, Beijing, China;Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 100070, Beijing, China;Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 100070, Beijing, China;Center of Stroke, Beijing Institute for Brain Disorders, 10069, Beijing, China;Department of Neurosurgery, Peking University International Hospital, 102206, Beijing, China;Department of Neurosurgery, Peking University International Hospital, 102206, Beijing, China;Department of Radiology, Chinese PLA General Hospital, Beijing, China;

关键词: Moyamoya disease;    Stroke;    SBM;    Cortical complexity;    Fractal dimension;    Cognitive dysfunction;   

DOI  :  10.1186/s12868-021-00672-x

来源: Springer

【 摘 要 】

BackgroundMoyamoya disease (MMD) is an uncommon cerebrovascular disease which leads to progressive stenosis and occlusion of the bilateral internal carotid artery and main intracerebral arteries. Concerns are always on how the hemisphere with infarction affects cognitive function, while little attention is paid to the role that the non-infarcted hemisphere plays. Therefore, we aimed to detect cortical indexes, especially cortical complexity in the left or right hemisphere separately in patients with MMD after stroke.Methods28 patients with MMD (14 males, 14 females) and 14 healthy controls were included in this study. All participants underwent cognitive tests and magnetic resonance imaging (MRI) scan. The preprocessing of three-dimensional T1 weighted images were performed by standard surface-based morphometry. Surface-based morphometry statistical analysis was carried out with a threshold of False Discovery Rate (FDR) P < 0.05 and fractal dimension (FD) was used to provide a quantitative description of cerebral cortical complexity.ResultsWidespread cognitive dysfunctions were found in MMD patient with stroke. Extensive FD reduction in the left hemisphere with right-sided infarction, mainly in the superior temporal, inferior frontal, and insula, while the post central gyrus, superior parietal, and inferior parietal gyrus also showed a wide range of significant differences (FDR corrected P < 0.05). Meanwhile, FD changes in the right hemisphere with left-sided infarction are restricted to the precuneus and cingulate isthmus (FDR corrected P < 0.05).ConclusionsExtensive cognitive impairment was reconfirmed in Moyamoya disease with stroke, while wild and asymmetrical decrease of cortical complexity is observed on both sides. These differences could be relative to unbalanced cognitive dysfunction, and may be the result of a long-term chronic ischemia and compensatory of the contralateral hemisphere to the infarction.

【 授权许可】

CC BY