Monitoring coagulation-fibrinolysis activation prompted timely diagnosis of hemophagocytic lymphohistiocytosis-related disseminated intravascular coagulation

Thrombosis Journal

Jing Zhou¹  Liqin Ling¹  Xunbei Huang¹  Juan Liao¹  Chaonan Liu¹ 

[1] Department of Laboratory Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, 610041, Chengdu, Sichuan, China;

关键词: Coagulation;    Fibrinolysis;    Hemophagocytic lymphohistiocytosis;    Disseminated intravascular coagulation;   

DOI  :  10.1186/s12959-021-00338-y

来源: Springer

【 摘 要 】

BackgroundTimely diagnosis of disseminated intravascular coagulation (DIC) in hemophagocytic lymphohistiocytosis (HLH) patients is crucial but challenging, as HLH interferes with the results of the laboratory tests included in the DIC score system.Case presentationHere, we reported a case of lymphoma-associated HLH, in which coagulation-fibrinolysis activation /inhibition markers (TAT, tPAIC, and PIC), prompted timely diagnosis of early stage DIC (initial phase of microvascular thrombosis, yet non-overt), prior to the development of organ failures and/or bleedings.ConclusionsThis report highlights the importance of the implementation of new biomarkers (such as TAT, tPAIC, and PIC), into the diagnostic work-up for coagulation disorders. These biomarkers are directly suggestive of microthrombus formation, therefore they can be of paramount importance in diagnosing DIC with complicated etiologies, such as hematological diseases-related DIC.

【 授权许可】

CC BY