Cell-derived extracellular vesicles and membranes for tissue repair

Journal of Nanobiotechnology

Zhongquan Sun¹  Yanjie Li¹  Xin Han¹  Weilin Wang¹  Yining Chen¹  Yuan Ding¹  Zhengwei Mao²  Yao Ge³ 

[1] Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, Zhejiang, China;Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, 310009, Hangzhou, Zhejiang, China;Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, 310009, Hangzhou, Zhejiang, China;Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University, 310009, Hangzhou, Zhejiang, China;Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, 310009, Hangzhou, Zhejiang, China;Zhejiang University Cancer Center, 310009, Hangzhou, Zhejiang, China;Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, 310009, Hangzhou, Zhejiang, China;MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, 310027, Hangzhou, Zhejiang, China;Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, 310009, Hangzhou, Zhejiang, China;Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, 310009, Hangzhou, Zhejiang, China;Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University, 310009, Hangzhou, Zhejiang, China;Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, 310009, Hangzhou, Zhejiang, China;Zhejiang University Cancer Center, 310009, Hangzhou, Zhejiang, China;

关键词: Cell membrane;    Extracellular vesicles;    Cell therapy;    Regenerative medicine;    Biomaterials;    Stem cells;   

DOI  :  10.1186/s12951-021-01113-x

来源: Springer

【 摘 要 】

Humans have a limited postinjury regenerative ability. Therefore, cell-derived biomaterials have long been utilized for tissue repair. Cells with multipotent differentiation potential, such as stem cells, have been administered to patients for the treatment of various diseases. Researchers expected that these cells would mediate tissue repair and regeneration through their multipotency. However, increasing evidence has suggested that in most stem cell therapies, the paracrine effect but not cell differentiation or regeneration is the major driving force of tissue repair. Additionally, ethical and safety problems have limited the application of stem cell therapies. Therefore, nonliving cell-derived techniques such as extracellular vesicle (EV) therapy and cell membrane-based therapy to fulfil the unmet demand for tissue repair are important. Nonliving cell-derived biomaterials are safer and more controllable, and their efficacy is easier to enhance through bioengineering approaches. Here, we described the development and evolution from cell therapy to EV therapy and cell membrane-based therapy for tissue repair. Furthermore, the latest advances in nonliving cell-derived therapies empowered by advanced engineering techniques are emphatically reviewed, and their potential and challenges in the future are discussed.Graphical Abstract

【 授权许可】

CC BY