Associations between dynamic-contrast enhanced MRI and tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer

Cancer Imaging

Hans-Jonas Meyer¹  Anne Kathrin Höhn²  Alexey Surov³ 

[1] Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany;Department of Pathology, University of Leipzig, Leipzig, Germany;Department of Radiology and Nuclear Medicine, University of Magdeburg, Magdeburg, Germany;

关键词: Head and neck squamous cell cancer;    Dynamic contrast enhanced-MRI;    Tumor infiltrating lymphocyte;    Histogram analysis;   

DOI  :  10.1186/s40644-021-00429-z

来源: Springer

【 摘 要 】

ObjectivesThe present study used dynamic-contrast enhanced MRI (DCE-MRI) to elucidate possible associations with tumor-infiltrating lymphocytes (TIL), stroma ratio and vimentin expression in head and neck squamous cell cancer (HNSCC).MethodsOverall, 26 patients with primary HNSCC of different localizations were involved in the study. DCE-MRI was obtained on a 3 T MRI and analyzed with a whole lesion measurement using a histogram approach. TIL- and vimentin-expression was calculated on bioptic samples before any form of treatment. P16 staining was used to define HPV-status.ResultsTumor-stroma ratio correlated with entropy derived from Ktrans (r = − 0.52, p = 0.0071) and with kurtosis derived from Ve (r = − 0.53, p = 0.0058).Several Ve derived parameters correlated with expression of TIL within the stroma compartment. TIL within the tumor compartment correlated with entropy derived from Ktrans (r = 0.39, p = 0.047), p90 derived from Ve (r = 0.41, p = 0.036) and skewness derived from Ve (r = 0.41, p = 0.037). Furthermore, these associations were different between HPV positive and negative tumors.ConclusionsDCE-MRI might be able to reflect tumor compartments and TIL expression in HNSCC. The most promising parameters were values derived from Ktrans and Ve.

【 授权许可】

CC BY