Thymol-loaded PLGA nanoparticles: an efficient approach for acne treatment

Journal of Nanobiotechnology

Laura Baldoma¹  Josefa Badia¹  Natalia Díaz-Garrido¹  Ana M. Marqués²  Camila Folle³  Ana Cristina Calpena⁴  Elena Sánchez-López⁴  Maria Luisa García⁴  Marta Espina⁴ 

[1] Department of Biochemistry and Physiology, Biochemistry and Biomolecular Science, University of Barcelona, 08028, Barcelona, Spain;Institute of Biomedicine of the University of Barcelona (IBUB), 08028, Barcelona, Spain;Research Institute Sant Joan De Déu (IR-SJD), 08950, Barcelona, Spain;Department of Biology, Healthcare and Environment, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain;Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain;Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain;Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028, Barcelona, Spain;

关键词: Acne;    Thymol;    PLGA nanoparticles;    Skin delivery system;    Cutibacterium acnes;    Skin microbiota;    Antimicrobial;    Antioxidant;   

DOI  :  10.1186/s12951-021-01092-z

来源: Springer

【 摘 要 】

BackgroundAcne is a common skin disorder that involves an infection inside the hair follicle, which is usually treated with antibiotics, resulting in unbalanced skin microbiota and microbial resistance. For this reason, we developed polymeric nanoparticles encapsulating thymol, a natural active compound with antimicrobial and antioxidant properties. In this work, optimization physicochemical characterization, biopharmaceutical behavior and therapeutic efficacy of this novel nanostructured system were assessed.ResultsThymol NPs (TH-NP) resulted on suitable average particle size below 200 nm with a surface charge around − 28 mV and high encapsulation efficiency (80%). TH-NP released TH in a sustained manner and provide a slow-rate penetration into the hair follicle, being highly retained inside the skin. TH-NP possess a potent antimicrobial activity against Cutibacterium acnes and minor effect towards Staphylococcus epidermis, the major resident of the healthy skin microbiota. Additionally, the stability and sterility of developed NPs were maintained along storage.ConclusionTH-NP showed a promising and efficient alternative for the treatment of skin acne infection, avoiding antibiotic administration, reducing side effects, and preventing microbial drug resistance, without altering the healthy skin microbiota. Additionally, TH-NP enhanced TH antioxidant activity, constituting a natural, preservative-free, approach for acne treatment.Graphical Abstract

【 授权许可】

CC BY