The temporal relationship between parental concern of overeating and childhood obesity considering genetic susceptibility: longitudinal results from the IDEFICS/I.Family study

International Journal of Behavioral Nutrition and Physical Activity

Toomas Veidebaum¹  Leonie H. Bogl²  Dénés Molnar³  Stefaan De Henauw⁴  Guiomar Masip⁵  Anna Keski-Rahkonen⁵  Jaakko Kaprio⁶  Karri Silventoinen⁷  Roger A. H. Adan⁸  Luis A. Moreno⁹  Paola Russo^1,10  Ronja Foraita^1,11  Antje Hebestreit^1,11  Iris Pigeot^1,12  Wolfgang Ahrens^1,12  Lauren Lissner^1,13  Kirsten Mehlig^1,13 

[1] Department of Chronic Diseases, National Institute for Health Development, Tallinn, Estonia;Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria;Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland;Department of Paediatrics, Medical School, University of Pécs, Pécs, Hungary;Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium;Department of Public Health, University of Helsinki, Helsinki, Finland;Department of Public Health, University of Helsinki, Helsinki, Finland;Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland;Department of Public Health, University of Helsinki, Helsinki, Finland;Population Research Unit, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland;Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands;GENUD (Growth, Exercise, Nutrition and Development) Research Group, Faculty of Health Sciences, University of Zaragoza Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria de Aragón, Zaragoza, Spain;Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain;Institute of Food Sciences, National Research Council, Avellino, Italy;Leibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, Germany;Leibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, Germany;Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany;School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;

关键词: Obesity;    Overeating;    Polygenic risk score;    Body mass index;    Genetics;    Temporal associations;    Mediation;   

DOI  :  10.1186/s12966-021-01205-9

来源: Springer

【 摘 要 】

BackgroundMany genes and molecular pathways are associated with obesity, but the mechanisms from genes to obesity are less well known. Eating behaviors represent a plausible pathway, but because the relationships of eating behaviors and obesity may be bi-directional, it remains challenging to resolve the underlying pathways. A longitudinal approach is needed to assess the contribution of genetic risk during the development of obesity in childhood. In this study we aim to examine the relationships between the polygenic risk score for body mass index (PRS-BMI), parental concern of overeating and obesity indices during childhood.MethodsThe IDEFICS/I.Family study is a school-based multicenter pan-European cohort of children observed for 6 years (mean ± SD follow-up 5.8 ± 0.4). Children examined in 2007/2008 (wave 1) (mean ± SD age: 4.4 ± 1.1, range: 2–9 years), in 2009/2010 (wave 2) and in 2013/2014 (wave 3) were included. A total of 5112 children (49% girls) participated at waves 1, 2 and 3. For 2656 children with genome-wide data we constructed a PRS based on 2.1 million single nucleotide polymorphisms. Z-score BMI and z-score waist circumference (WC) were assessed and eating behaviors and relevant confounders were reported by parents via questionnaires. Parental concern of overeating was derived from principal component analyses from an eating behavior questionnaire.ResultsIn cross-lagged models, the prospective associations between z-score obesity indices and parental concern of overeating were bi-directional. In mediation models, the association between the PRS-BMI and parental concern of overeating at wave 3 was mediated by baseline z-BMI (β = 0.16, 95% CI: 0.10, 0.21) and baseline z-WC (β = 0.17, 95% CI: 0.11, 0.23). To a lesser extent, baseline parental concern of overeating also mediated the association between the PRS-BMI and z-BMI at wave 3 (β = 0.10, 95% CI: 0.07, 0.13) and z-WC at wave 3 (β = 0.09, 95% CI: 0.07, 0.12).ConclusionsThe findings suggest that the prospective associations between obesity indices and parental concern of overeating are likely bi-directional, but obesity indices have a stronger association with future parental concern of overeating than vice versa. The findings suggest parental concern of overeating as a possible mediator in the genetic susceptibility to obesity and further highlight that other pathways are also involved. A better understanding of the genetic pathways that lead to childhood obesity can help to prevent weight gain.Trial registrationRegistry number: ISRCTN62310987 Retrospectively registered 17 September 2018.

【 授权许可】

CC BY