Health-related quality of life for adults living with hepatitis B in the United States: a qualitative assessment

Journal of Patient-Reported Outcomes

Stuart Kendrick¹  Maureen Kamischke²  Catherine Freeland²  Chari Cohen²  Kate Moraras²  Evangeline Wang²  Rhea Racho² 

[1] FRCP GSK Research and Development, Stevenage, UK;Hepatitis B Foundation, 3805 Old Easton Rd., 18902, Doylestown, PA, USA;

关键词: Hepatitis B Virus (HBV);    Health related quality of life (HRQL);    Patient reported outcomes (PRO);    Viral hepatitis;    Liver disease;    Liver cancer;    Patient experience;    Antiviral therapy;   

DOI  :  10.1186/s41687-021-00398-8

来源: Springer

【 摘 要 】

BackgroundIn 2019, an estimated 296 million people were living with chronic hepatitis B virus (HBV) globally with approximately 2.4 million living within the United States. Those living with HBV require years if not decades of regular monitoring to prevent liver complications from occurring. The aim of this study was to explore the working conceptual framework of health related quality of life (HRQL) for those living with chronic HBV through qualitative analysis.MethodsData were collected by in-depth telephone interviews conducted in 2019 using purposeful sampling as part of a disease understanding assessment on the HBV patient experience within the United States. A directed content analysis approach was utilized by creation of a codebook to guide the organization of data, codes were developed by review of the literature (a priori) and through line-by-line reading of a subsample of queries. All transcripts were analyzed by at least two members of the study team and intercoder reliability was assessed using Dedoose software.FindingsA sample of 19 individuals living with chronic HBV were included within this study. Themes identified from transcripts noted the significant overlap between the reported experience of HBVand constructs within the HRQL model. The psychological impact of chronic HBV on study participants’ HRQL overall was considerable and contributed to depression, anxiety, homelessness, drug use, and incarceration.ConclusionOur analysis supports the hypothesis that HBV impacts HRQL and often negatively affects emotional health. Our findings suggest that it would be beneficial to include HRQL assessment in the medical management of HBV, so that interventions can focus on reducing the burden of disease and improving quality of life for those living with HBV.

【 授权许可】

CC BY