Effect and implementation experience of intensive adherence counseling in a public HIV care center in Uganda: a mixed-methods study

BMC Infectious Diseases

David Mukunya¹  Thomas Katairo²  Rhoda K. Wanyenze³  Samuel Etajak³  Aloysius Ssenyonjo³  Moses Tetui⁴  Zubair Lukyamuzi⁵ 

[1] Busitema University Faculty of Health Sciences, Mbale, Uganda;Sanyu Africa Research Institute, Mbale, Uganda;Infectious Diseases Research Collaboration, Kampala, Uganda;Makerere University College of Health Sciences, School of Public Health, Kampala, Uganda;Makerere University College of Health Sciences, School of Public Health, Kampala, Uganda;School of Pharmacy, Waterloo University, Waterloo, ON, Canada;Department of Epidemiology and Global Health, Umeå University, 901 87, Umeå, Sweden;Makerere University, Johns Hopkins University Collaboration (MU-JHU), Upper Mulago Hill Road, Kampala, Uganda;Makerere University College of Health Sciences, School of Public Health, Kampala, Uganda;

关键词: Intensive adherence counseling;    People living with HIV;    Unsuppressed viral load;    Public HIV care center;    Uganda;   

DOI  :  10.1186/s12879-021-06862-6

来源: Springer

【 摘 要 】

BackgroundIntensive adherence counseling (IAC) is an intervention recommended by the World Health Organization to improve anti-retroviral therapy (ART) adherence among people living with HIV on ART with unsuppressed viral load; and in 2016, the intervention was implemented in Uganda. This study evaluated the effect and experiences of providing IAC in an urban HIV care center in Kampala, Uganda.MethodsThis was a sequential explanatory mixed-method study that compared viral load suppression during IAC implementation (intervention) to the period before IAC at Kisenyi Health centre IV. Data were abstracted from patient files and viral load register. The effect of IAC on viral load suppression and associated factors were analyzed using modified Poisson regression with robust standard errors. Using in-depth interviews and an inductive analysis approach in Atlas-ti 8. We also explored experiences of providing IAC among healthcare workers.ResultsA total of 500 records were sampled: 249 (49.8%) in the intervention period and 251 (51.2%) in the pre-intervention period. The mean age was lower during the intervention period 33.1 (± 12.0) than 36.5 (± 13.4) in the pre- intervention period, p = 0.002. More clients were currently on Protease-based regimen in the pre-intervention period 179 (71.3%) than 135 (54.2%) in the intervention period, p ≤ 0.001. In the intervention period, all eligible clients received IAC [249/249 (100.0%)]. Overall, 325 (65.0%) received IAC and of these, 143 (44.1%) achieved viral load suppression compared to 46 (26.3%) who received regular counseling. Receiving IAC significantly increased viral load suppression by 22% (aPR 1.22, 95% CI 1.01–1.47). Clients on Protease-based regimen were less likely to suppress than those on Efavirenz or Nevirapine-based regimens (aPR 0.11, 95% CI 0.08–0.15). All the interviewed healthcare workers lauded IAC for improving ART adherence. However, patient and health care system related factors hindered adherence during IAC.ConclusionsThe full potential of IAC in achieving viral load suppression in this setting has not been reached due to a combination of the patient and health care system related factors. Provision of adequate IAC necessities and use of patient centered approach should be emphasized to obtain the maximum benefit of the intervention.

【 授权许可】

CC BY