Mediation and moderation analyses: exploring the complex pathways between hope and quality of life among patients with schizophrenia

BMC Psychiatry

Guo-Hua Li¹  Nan-Nan Chai²  Wei-Liang Wang³  Dong-Wei Liu³  Yu-Qiu Zhou³ 

[1] Chifeng Anding Hospital, Chifeng, the Autonomous Region, China;School of Nursing, Chifeng University, Chifeng, the Autonomous Region, China;School of Nursing, Harbin Medical University (Daqing), Daqing, Heilongjiang, China;

关键词: Schizophrenia;    Quality of life;    Moderated mediation;    Hope;    Resilience;    Depression;   

DOI  :  10.1186/s12888-020-2436-5

来源: Springer

【 摘 要 】

BackgroundThe underlying mechanism between hope and quality of life is as yet unknown. We aim to examine the potential mediating effect of depression and resilience and the moderated effect of sex in this well-established association.MethodsTwo hundred seven patients diagnosed with schizophrenia were administered a questionnaire battery that measured hope, depression, resilience and QOL. A multiple mediation model was used to examine the mediating effect of resilience and depression on the association between hope and QOL. A subgroup analysis was performed and a moderated mediation model was examined to find and test the moderated effect of sex on the mediation model. We used Mplus to perform moderation and mediation analyses so that the mediators and moderator could function together in the same model.ResultSex was the moderator on the direct path between hope and QOL. The relationship between hope and QOL was mediated by resilience and depression in both sexes. When compared with female patients, the effect of hope on QOL was completely mediated by resilience and depression in males. In female patients, the model was partially mediated, and the direct effect of hope on QOL was significantly negatively correlated with the level of hope.ConclusionWe present a conceptual model containing the mediated effects of resilience and depression and the moderated effect of sex between hope and QOL, which we believe facilitates the understanding of these associations. This model should be useful in the formulation of strategies to improve QOL.

【 授权许可】

CC BY