Inferior vena cava collapsibility index as a predictor of fluid responsiveness in sepsis-related acute circulatory failure

Ain-Shams Journal of Anesthesiology

Amira Fathy Hefny¹  Amr Mohamed Abdel Fatah¹  Azza Mohamed Shafik¹  Ahmed Ibrahim Nagi¹  Wessam Zaher Selima¹ 

[1] Department of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Ain-Shams University, Abbassia, 11591, Cairo, Egypt;

关键词: Inferior vena cava collapsibility index;    IVC max;    IVC min;    Ultrasonography;    Echocardiography;    Stroke volume;    Cardiac output;    Fluid responsiveness;    Sepsis;    Acute circulatory failure;   

DOI  :  10.1186/s42077-021-00194-y

来源: Springer

【 摘 要 】

BackgroundAssessing fluid responsiveness is the key to successful resuscitation of critically-ill sepsis patients. The use of IVC variation is favored among the dynamic methods of fluid responsiveness assessment in the ICU because it is non-invasive and inexpensive; moreover, it does not demand a high level of training. The aim of this study is to determine the value of the IVC respiratory variability for predicting fluid responsiveness in spontaneously breathing sepsis patients with acute circulatory failure.ResultsIn this prospective observational study, fifty-eight spontaneously breathing sepsis patients admitted in the ICU were enrolled after the approval of the departmental Research Ethical Committee, and the informed written consent had been taken from the patients. Ultrasonographic and echocardiographic parameters were measured “IVC parameters and stroke volume (SV)” with calculation of the inferior vena cava collapsibility index (IVCCI) and cardiac output. These values were obtained before (baseline) and after volume expansion with a fluid bolus. The study showed that twenty-nine patients (50%) were considered to be responders, with an increase in CO by 10% or more after fluid challenge. There was a significant difference between responders and non-responders in baseline IVCCI (p value < 0.001). There were no significant differences between responders and non-responders in terms of demographic and baseline clinical characteristics. Also, there was statistically significantly larger maximum (IVC max) and minimum (IVC min) inferior vena cava diameters before volume expansion in non-responders than in responders with p value 0.037 and 0.001 respectively. The suggested cut off value regarding baseline IVCCI to predict response to fluid infusion is 0.32 with a high chance of response above this figure (a sensitivity of 72.41% and a specificity of 82.76%).ConclusionsInferior vena cava collapsibility index assessment can be a sensitive and a good predictor of fluid responsiveness, being based on a safe and a non-invasive technique compared to other methods such as central venous pressure (CVP) measurement and pulmonary artery catheter insertion.

【 授权许可】

CC BY