Clinical applications of concentrated growth factors combined with bone substitutes for alveolar ridge preservation in maxillary molar area: a randomized controlled trial

International Journal of Implant Dentistry

Jun Li¹  Fang Wu²  Xin Li³  Ya Su³  Shao-yu Duan³  Hang Liu³  Lian Yang³  Shi-chen Lin³ 

[1] Department of Implant Dentistry, Beijing Stomatological Hospital, Capital Medical University, No.4 Tiantan Xili, Dongcheng District, 100050, Beijing, China;Department of Pathology, Electric Power Teaching Hospital, Capital Medical University, No.1, Taipingqiao Xili, Fengtai District, 100073, Beijing, China;Department of Stomatology, Electric Power Teaching Hospital, Capital Medical University, No.1, Taipingqiao Xili, Fengtai District, 100073, Beijing, China;

关键词: Alveolar ridge preservation;    CGFs;    DBBM;    Radiography;    Histology;   

DOI  :  10.1186/s40729-021-00396-x

来源: Springer

【 摘 要 】

PurposeTo evaluate the clinical effects of concentrated growth factors (CGFs) combined with bone substitutes for alveolar ridge preservation (ARP) in the maxillary molar area.MethodsThirty-six patients who underwent extraction of the upper molars were recruited and randomly divided into three groups: 1. Grafted with CGFs combined with deproteinized bovine bone mineral (DBBM) and covered with CGFs membrane (CGFs/DBBM group), 2. Grafted with DBBM alone and covered with collagen membrane (DBBM group), 3. Control group spontaneous healing. The area of the alveolar bone in center (C-), mesial (M-) and distal (D-) section was compared with preoperative in radiography. Bone cores were obtained for histopathology observation and comparison.ResultsIn C-, M- and D-section, the alveolar ridge area in all three groups was significantly reduced at 8 months postoperatively compared to the baseline (P < 0.05). The alveolar ridge area declines in the CGFs/DBBM group (C-12.75 ± 2.22 mm2, M-14.69 ± 2.82 mm2, D-16.95 ± 4.17 mm2) and DBBM group (C-14.08 ± 2.51 mm2, M-15.42 ± 3.47 mm2, D-16.09 ± 3.97 mm2) were non-significant differences. They were significantly less than the decline in the control group (C-45.04 ± 8.38 mm2 M-31.98 ± 8.34 mm2, D-31.85 ± 8.52 mm2) (P < 0.05). The percentage of newly formed bone in the CGFs/DBBM group (41.99 ± 12.99%) was significantly greater than that in DBBM group (30.68 ± 10.95%) (P < 0.05). The percentage of residual materials in the CGFs/DBBM group (16.19 ± 6.63%) was significantly less than that in the DBBM group (28.35 ± 11.70%) (P < 0.05).ConclusionCombined application of CGFs and DBBM effectively reduced the resorption of alveolar ridge and resulted in more newly formed bone than the use of DBBM with collagen membranes.

【 授权许可】

CC BY