Predictors of the chest CT score in COVID-19 patients: a cross-sectional study

Virology Journal

Ladan Abbasian¹  Mahboubeh Hajiabdolbaghi¹  Malihe Hasannezad¹  Zahra Ahmadinejad¹  Mohammadreza Salehi¹  Mohsen Meidani¹  Hamid Emadi Koochak¹  Seyed Ali Dehghan Manshadi¹  Fatemeh Jafari¹  Sirous Jafari¹  Hossein Khalili²  Abdolkarim Haji Ghadery³  Mohammad-Mehdi Mehrabinejad³  Niloofar Ayoobi Yazdi⁴  Seyed Ahmad Seyedalinaghi⁵ 

[1]Department of Infectious Diseases, Imam Khomeini Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Blv. Keshavarz, Tehran, Iran

[2]Department of Pharmacotherapy, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

[3]Department of Radiology, Advanced Diagnostic and Interventional Radiology Research Center(ADIR), Tehran University of Medical Sciences, Tehran, Iran

[4]Department of Radiology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

[5]Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran

关键词: COVID-19;    Computed tomography;    Outcome;    Recovery;    Chest CT score;   

DOI  :  10.1186/s12985-021-01699-6

来源: Springer

【 摘 要 】

BackgroundSince the COVID-19 outbreak, pulmonary involvement was one of the most significant concerns in assessing patients. In the current study, we evaluated patient’s signs, symptoms, and laboratory data on the first visit to predict the severity of pulmonary involvement and their outcome regarding their initial findings.MethodsAll referred patients to the COVID-19 clinic of a tertiary referral university hospital were evaluated from April to August 2020. Four hundred seventy-eight COVID-19 patients with positive real-time reverse-transcriptase-polymerase chain reaction (RT-PCR) or highly suggestive symptoms with computed tomography (CT) imaging results with typical findings of COVID-19 were enrolled in the study. The clinical features, initial laboratory, CT findings, and short-term outcomes (ICU admission, mortality, length of hospitalization, and recovery time) were recorded. In addition, the severity of pulmonary involvement was assessed using a semi-quantitative scoring system (0–25).ResultsAmong 478 participants in this study, 353 (73.6%) were admitted to the hospital, and 42 (8.7%) patients were admitted to the ICU. Myalgia (60.4%), fever (59.4%), and dyspnea (57.9%) were the most common symptoms of participants at the first visit. A review of chest CT scans showed that Ground Glass Opacity (GGO) (58.5%) and consolidation (20.7%) were the most patterns of lung lesions. Among initial clinical and laboratory findings, anosmia (P = 0.01), respiratory rate (RR) with a cut point of 25 (P = 0.001), C-reactive protein (CRP) with a cut point of 90 (P = 0.002), white Blood Cell (WBC) with a cut point of 10,000 (P = 0.009), and SpO2 with a cut point of 93 (P = 0.04) was associated with higher chest CT score. Lung involvement and consolidation lesions on chest CT scans were also associated with a more extended hospitalization and recovery period.ConclusionsInitial assessment of COVID-19 patients, including symptoms, vital signs, and routine laboratory tests, can predict the severity of lung involvement and unfavorable outcomes.

【 授权许可】

CC BY