In adults, early mobilization may be beneficial for distal radius fractures treated with open reduction and internal fixation: a systematic review and meta-analysis

Journal of Orthopaedic Surgery and Research

FuBing Li¹  ZhiBo Deng²  JiangPing Wu²  KaiYing Tang²  Han Shu²  Ting Wang²  Mao Nie² 

[1] Department of Orthopaedic Surgery, 920Th Hospital of Joint Logistics Support Force, 650032, Kunming, Yunnan Province, China;Department of Orthopaedic Surgery, Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China;

关键词: Meta-analysis;    Distal radius fracture;    Open reduction internal fixation;    Early mobilization;    Late mobilization;   

DOI  :  10.1186/s13018-021-02837-0

来源: Springer

【 摘 要 】

ObjectivesIt remains debatable if early mobilization (EM) yields a better clinical outcome than the late mobilization (LM) in adults with an acute and displaced distal radial fracture (DRF) of open reduction internal fixation (ORIF). Therefore, we aimed to perform a systematic review and meta-analysis of randomized controlled trials (RCTs), comparing clinical results with the safety of EM with LM following ORIF.MethodsDatabases such as Medline, Cochrane Central Register, and Embase were searched from Jan 1, 2000, to July 31, 2021, and RCTs comparing EM with LM for DRF with ORIF were included in the analysis. The primary outcome of study included disabilities of the Arm, Shoulder, and Hand (DASH) score at different follow-up times. Wherever the secondary outcomes included patient-rated wrist evaluation (PRWE), grip strength (GS), visual analog scale (VAS), wrist range of motion (WROM), and associated complications, the two independent reviewers did data extraction for the analysis. Effect sizes of outcome for each group were pooled using random-effects models; thereafter, the results were represented in the forest plots.ResultsNine RCTs with 293 EM and 303 LM participants were identified and included in the study. Our analysis showed that the DASH score of the EM group was significantly better than LM group at the six weeks postoperatively (− 10.15; 95% CI − 15.74 to − 4.57, P < 0.01). Besides, the EM group also had better outcomes in PRWE, GS and WROM at 6 weeks. However, EM showed potential higher rate for implant loosening and/or fracture re-displacement complication (3.00; 95% CI 1.02–8.83, P = 0.05).ConclusionFunctionally, at earlier stages, EM for patients with DRF of ORIF may have a beneficial effect than LM. The mean differences in the DASH score at 6 weeks surpassed the minimal clinically important difference; however, the potentially higher risk of implant loosening and/or fracture re-displacement cannot be ignored. Due to the lack of definitive evidence, multicenter and large sample RCTs are required for determining the optimal rehabilitation protocol for DRF with ORIF.PROSPERO registration number: CRD42021240214 2021/2/28.

【 授权许可】

CC BY