Dye-loaded mesoporous polydopamine nanoparticles for multimodal tumor theranostics with enhanced immunogenic cell death

Journal of Nanobiotechnology

Xiang Liao¹  Shouju Wang¹  Guangming Lu¹  Longjiang Zhang¹  Ying Tian¹  Yuxia Tang¹  Zhaogang Teng²  Gang He³  Peng Huang³  Muhammad Rizwan Younis³ 

[1] Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 210002, Nanjing, People’s Republic of China;State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 210093, Nanjing, People’s Republic of China;Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials, Nanjing University of Posts & Telecommunications, 210023, Nanjing, People’s Republic of China;Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, 518060, Shenzhen, People’s Republic of China;

关键词: Mesoporous polydopamine nanoparticles;    IR-780;    Photodynamic therapy;    Photothermal therapy;    Immunogenic cell death;   

DOI  :  10.1186/s12951-021-01109-7

来源: Springer

【 摘 要 】

BackgroundTumor phototherapy especially photodynamic therapy (PDT) or photothermal therapy (PTT), has been considered as an attractive strategy to elicit significant immunogenic cell death (ICD) at an optimal tumor retention of PDT/PTT agents. Heptamethine cyanine dye (IR-780), a promising PDT/PTT agent, which can be used for near-infrared (NIR) fluorescence/photoacoustic (PA) imaging guided tumor phototherapy, however, the strong hydrophobicity, short circulation time, and potential toxicity in vivo hinder its biomedical applications. To address this challenge, we developed mesoporous polydopamine nanoparticles (MPDA) with excellent biocompatibility, PTT efficacy, and PA imaging ability, facilitating an efficient loading and protection of hydrophobic IR-780.ResultsThe IR-780 loaded MPDA (IR-780@MPDA) exhibited high loading capacity of IR-780 (49.7 wt%), good physiological solubility and stability, and reduced toxicity. In vivo NIR fluorescence and PA imaging revealed high tumor accumulation of IR-780@MPDA. Furthermore, the combined PDT/PTT of IR-780@MPDA could induce ICD, triggered immunotherapeutic response to breast tumor by the activation of cytotoxic T cells, resulting in significant suppression of tumor growth in vivo.ConclusionThis study demonstrated that the as-developed compact and biocompatible platform could induce combined PDT/PTT and accelerate immune activation via excellent tumor accumulation ability, offering multimodal tumor theranostics with negligible systemic toxicity.Graphical Abstract

【 授权许可】

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