Endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer

World Journal of Surgical Oncology

Yoshihito Nomoto¹  Makiko Kubooka²  Shinji Kaneda³  Koji Kawaguchi³  Motoshi Takao³  Akira Shimamoto³  Atsushi Ito³  Daisuke Yamaguchi³ 

[1]Department of Radiation Oncology, Graduate School of Medicine, Mie University, Tsu, Japan

[2]Department of Radiology, Graduate School of Medicine, Mie University, Tsu, Japan

[3]Department of Thoracic and Cardiovascular Surgery, Graduate School of Medicine, Mie University, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan

关键词: Endobronchial metastasis;    Endobronchial brachytherapy;    Definitive treatment;   

DOI  :  10.1186/s12957-021-02434-9

来源: Springer

【 摘 要 】

BackgroundEndobronchial metastasis is a very rare type of recurrence after lung cancer surgery. Surgical intervention may be difficult to perform due to the postoperative reduction in the activities of daily living (ADL) and the invasiveness associated with redo surgery. In such cases, endobronchial brachytherapy (EBBT) plays an important role not only as a palliative treatment, but also as a definitive treatment with curative intent.Case presentationThree men (64, 69, and 74 years old) underwent combination therapy of external beam radiation therapy (EBRT) and EBBT for endobronchial metastasis after lobectomy of stage I–II non-small cell lung cancer (NSCLC): 2 cases of squamous cell carcinoma and 1 of adenocarcinoma. We used a special source-centralizing applicator for EBBT to avoid eccentric distribution of the radiation dose. Follow-up was considered to start from the end of brachytherapy. None of our patients experienced severe adverse events, and none needed extensive outpatient treatment. Local control was achieved in all cases by a bronchoscopic evaluation. All patients were alive after 31, 38, and 92 months of follow-up, respectively. In the adenocarcinoma patient, two metastases to the lung were discovered 3 years after EBBT, and the patient underwent partial wedge resection.ConclusionsEBBT may be a promising treatment with curative intent for endobronchial metastasis after surgery of NSCLC.

【 授权许可】

CC BY