The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies

Skeletal Muscle

Hongyang Xu¹  Holly Van Remmen² 

[1] Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, 73104, Oklahoma City, OK, USA;Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, 73104, Oklahoma City, OK, USA;Oklahoma City VA Medical Center, Oklahoma City, OK, USA;Department of Physiology, OUHSC, Oklahoma City, OK, USA;

关键词: Skeletal muscle;    SERCA;    Calcium homeostasis;    Aging;    Neuromuscular disorder;    Oxidative stress;   

DOI  :  10.1186/s13395-021-00280-7

来源: Springer

【 摘 要 】

As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the sarcoplasmic reticulum (SR) following muscle contraction. SERCA function is closely associated with muscle health and function, and SERCA activity is susceptible to muscle pathogenesis. For example, it has been well reported that pathological conditions associated with aging, neurodegeneration, and muscular dystrophy (MD) significantly depress SERCA function with the potential to impair intracellular calcium homeostasis and further contribute to muscle atrophy and weakness. As a result, targeting SERCA activity has attracted attention as a therapeutical method for the treatment of muscle pathologies. The interventions include activation of SERCA activity and genetic overexpression of SERCA. This review will focus on SERCA function and regulation mechanisms and describe how those mechanisms are affected under muscle pathological conditions including elevated oxidative stress induced by aging, muscle disease, or neuromuscular disorders. We also discuss the current progress and therapeutic approaches to targeting SERCA in vivo.

【 授权许可】

CC BY