The association between first and second wave COVID-19 mortality in Italy

BMC Public Health

Kenneth J. Rothman¹  Nicola Orsini²  Tommaso Filippini³  Silvia Di Federico³  Marco Vinceti⁴ 

[1] Department of Epidemiology, Boston University School of Public Health, Boston, MA, US;RTI Health Solutions, Research Triangle Park, Raleigh, NC, US;Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden;Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Section of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy;Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Section of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy;Department of Epidemiology, Boston University School of Public Health, Boston, MA, US;

关键词: COVID-19;    Epidemiology;    Mortality;    Public health;    SARS-CoV-2;    Waves;   

DOI  :  10.1186/s12889-021-12126-4

来源: Springer

【 摘 要 】

BackgroundThe relation between the magnitude of successive waves of the COVID-19 outbreak within the same communities could be useful in predicting the scope of new outbreaks.MethodsWe investigated the extent to which COVID-19 mortality in Italy during the second wave was related to first wave mortality within the same provinces. We compared data on province-specific COVID-19 2020 mortality in two time periods, corresponding to the first wave (February 24–June 30, 2020) and to the second wave (September 1–December 31, 2020), using cubic spline regression.ResultsFor provinces with the lowest crude mortality rate in the first wave (February–June), i.e. < 22 cases/100,000/month, mortality in the second wave (September–December) was positively associated with mortality during the first wave. In provinces with mortality greater than 22/100,000/month during the first wave, higher mortality in the first wave was associated with a lower second wave mortality. Results were similar when the analysis was censored at October 2020, before the implementation of region-specific measures against the outbreak. Neither vaccination nor variant spread had any role during the study period.ConclusionsThese findings indicate that provinces with the most severe initial COVID-19 outbreaks, as assessed through mortality data, faced milder second waves.

【 授权许可】

CC BY