Impact of COVID-19 and lockdowns on pulmonary embolism in hospitalized patients in France: a nationwide study

Respiratory Research

Jonathan Cottenet¹  Anne-Sophie Mariet²  Catherine Quantin³  Jacques Cadranel⁴  Lionel Piroth⁵  Pierre Tankere⁶  Guillaume Beltramo⁶  Philippe Bonniaud⁷  Pascale Tubert-Bitter⁸ 

[1]CHU de Dijon - Service de Biostatistique et d’Informatique Médicale, BP 77908, 21079, Dijon CEDEX, France

[2]University of Burgundy and Franche-Comté, Dijon, France

[3]CHU de Dijon - Service de Biostatistique et d’Informatique Médicale, BP 77908, 21079, Dijon CEDEX, France

[4]University of Burgundy and Franche-Comté, Dijon, France

[5]Clinical Investigation Center, Clinical Epidemiology/Clinical Trials Unit, Inserm, CIC 1432, Dijon, France

[6] Dijon University Hospital, Dijon, France

[7]CHU de Dijon - Service de Biostatistique et d’Informatique Médicale, BP 77908, 21079, Dijon CEDEX, France

[8]University of Burgundy and Franche-Comté, Dijon, France

[9]Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, High-Dimensional Biostatistics for Drug Safety and Genomics, CESP, Villejuif, France

[10]Clinical Investigation Center, Clinical Epidemiology/Clinical Trials Unit, Inserm, CIC 1432, Dijon, France

[11] Dijon University Hospital, Dijon, France

[12]Chest Department and Constitutive Center for Rare Pulmonary Disease, Hôpital Tenon, AP-HP, Inflammation-Immunopathology-Biotherapy Department (DHU i2B) and Sorbonne Université, 75020, Paris, France

[13]Clinical Investigation Center, Clinical Epidemiology/Clinical Trials Unit, Inserm, CIC 1432, Dijon, France

[14] Dijon University Hospital, Dijon, France

[15]Faculty of Medicine, University of Burgundy and Franche-Comté, Dijon, France

[16]Infectious Diseases Department, Dijon University Hospital, BP 77908, 21079, Dijon, France

[17]Reference Center for Rare Pulmonary Diseases, Pulmonary Medicine and Intensive Care Unit Department, Dijon University Hospital, BP 77908, 21079, Dijon, France

[18]Reference Center for Rare Pulmonary Diseases, Pulmonary Medicine and Intensive Care Unit Department, Dijon University Hospital, BP 77908, 21079, Dijon, France

[19]Faculty of Medicine, University of Burgundy and Franche-Comté, Dijon, France

[20]INSERM, LNC UMR1231, LipSTIC LabEx Team, Dijon, France

[21]Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, High-Dimensional Biostatistics for Drug Safety and Genomics, CESP, Villejuif, France

关键词: COVID-19;    Pulmonary embolism;    Medico-administrative data;    Hospital;    Lockdown;    SARS-COV2;   

DOI  :  10.1186/s12931-021-01887-6

来源: Springer

【 摘 要 】

BackgroundThis study assessed the impact of the COVID-19 epidemic on overall hospitalizations for pulmonary embolism (PE) in France in comparison with previous years, and by COVID-19 and non-COVID-19 status.MethodsHospitalization data (2017–2020) were extracted from the French National Discharge database (all public and private hospitals).We included all patients older than 18 years hospitalized during the 3 years and extracted PE status and COVID-19 status (from March 2020). Age, sex and risk factors for PE (such as obesity, cancer) were identified. We also extracted transfer to an intensive care unit (ICU) and hospital death. The number of PE and the frequency of death in patients in 2019 and 2020 were described by month and by COVID-19 status. Logistic regressions were performed to identify the role of COVID-19 among other risk factors for PE in hospitalized patients.ResultsThe overall number of patients hospitalized with PE increased by about 16% in 2020 compared with 2019, and mortality also increased to 10.3% (+ 1.2%). These increases were mostly linked to COVID-19 waves, which were associated with PE hospitalization in COVID-19 patients (PE frequency was 3.7%; 2.8% in non-ICU and 8.8% in ICU). The final PE odds ratio for COVID-19 hospitalized patients was 4 compared with other hospitalized patients in 2020.The analyses of PE in non-COVID-19 patients showed a 2.7% increase in 2020 compared with the previous three years.ConclusionIn 2020, the overall number of patients hospitalized with PE in France increased compared to the previous three years despite a considerable decrease in scheduled hospitalizations. Nevertheless, proactive public policy focused on the prevention of PE in all patients should be encouraged.

【 授权许可】

CC BY