Effectiveness of convalescent plasma therapy in eight non-intubated coronavirus disease 2019 patients in Indonesia: a case series

Journal of Medical Case Reports

Theresia Monica Rahardjo¹  Hernawati Permatasari²  Fitri Rahayu Sari²  Fajar Budiono²  C. H. R. Driantik Chuntari²  Elizabeth Yogipranata³  Ardian Hediyanto Naswan⁴ 

[1]Faculty of Medicine, Maranatha Christian University, Suria Sumantri 65, 40164, Bandung, West Java, Indonesia

[2]Primaya Hospital, Tangerang, Indonesia

[3]Primaya Hospital, Tangerang, Indonesia

[4]Eka Hospital, Pekanbaru, Indonesia

[5]Primaya Hospital, Tangerang, Indonesia

[6]Eka Hospital, Tangerang, Indonesia

关键词: Convalescent plasma therapy;    Non-intubated;    Case series;   

DOI  :  10.1186/s13256-021-03059-y

来源: Springer

【 摘 要 】

BackgroundSevere acute respiratory syndrome coronavirus 2, the cause of coronavirus disease 2019, has become a global pandemic. Currently, there is no definitive treatment for coronavirus disease 2019. Convalescent plasma therapy has become a potential specific curative method, while vaccines as protection modalities require further work.Case presentationEight non-intubated Indonesian patients, ages ranging from 40 to 74 years old, with coronavirus disease 2019 confirmed by viral Ribonucleid Acid (RNA) real-time polymerase chain reaction tests were included. Four patients were administered two doses of 200 mL convalescent plasma, and the other four patients were administered one dose of convalescent plasma with an antibody titer of 1:320, within the first 14 days since symptoms occurred. The median times from illness onset to convalescent plasma therapy and from the first day of hospital admission to convalescent plasma therapy were 13 and 6.5 days, respectively. All patients showed improvements in clinical symptoms, laboratory parameters, thorax imaging, negative conversion of polymerase chain reaction results, and decreased oxygen supplementation within 1 week after convalescent plasma therapy. Patients with two convalescent plasma doses tended to have faster recovery than those with one convalescent plasma dose. No severe adverse effects were observed in any patient.ConclusionThis is the first case series in Indonesia showing that convalescent plasma therapy is safe and well tolerated and that early convalescent plasma therapy before the patient is intubated could potentially prevent disease progression, increase the recovery rate, and shorten the inpatient time of stay.

【 授权许可】

CC BY