Evidence of extensive cellular immune response after SARS-CoV-2 vaccination in ocrelizumab-treated patients with multiple sclerosis

Neurological Research and Practice

Mosche Pompsch¹  Markus Kraemer²  Neslinur Fisenkci³  Peter A. Horn³  Monika Lindemann³ 

[1] Department of Neurology, Alfried Krupp Hospital, Alfried-Krupp-Straße 21, 45130, Essen, Germany;Department of Neurology, Alfried Krupp Hospital, Alfried-Krupp-Straße 21, 45130, Essen, Germany;Department of Neurology, Medical Faculty of Heinrich-Heine-University, Düsseldorf, Germany;Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany;

关键词: Ocrelizumab;    B-cell depleted patients;    SARS-CoV2 vaccination;    Comirnaty®;    T-cell mediated response;    Lack of antibody response;    Multiple sclerosis;    COVID-19;   

DOI  :  10.1186/s42466-021-00158-5

来源: Springer

【 摘 要 】

BackgroundPatients with multiple sclerosis receiving ocrelizumab-treatment are in desperate need of a protection against SARS-CoV-2 infection.MethodsIn this study, Euroimmun semi-quantitative Anti-SARS-CoV-2 IgG for detection of humoral response and ELISpot assays for detection of SARS-CoV-2-specific T-cell-response were used in 10 ocrelizumab-treated patients with multiple sclerosis twice vaccinated with Comirnaty® mRNA vaccine. This data was compared with a control group of 20 age- and sex-matched healthy volunteers, who had all previously received a full SARS-CoV-2 mRNA vaccination with Comirnaty® or Spikevax®.ResultsWhile all subjects in the control group had high humoral response to the vaccination, in B-cell-depleted individuals a significantly reduced antibody response to vaccination against SARS-CoV-2 was observed. SARS-CoV-2 specific T-cell-response, however, did not differ significantly between both cohorts.ConclusionsT-cell-mediated response to Comirnaty® vaccination is observable despite attenuated humoral response in B-cell-depleted patients. This might enable partial protection against COVID-19.Trial registration Retrospectively registered.

【 授权许可】

CC BY