Prevalence of Chronic Diseases and Alterations of Gut Microbiome in People of Ningxia China During Urbanization: An Epidemiological Survey

Frontiers in Cellular and Infection Microbiology

Li Na¹  Lu Ding¹  Yong Du²  Ting Sun³  Zhenhui Lu⁴  Feng Li⁵  Yanhong Zhang⁵  Xiaofei Guo⁵  Sifan Zhai⁶  Xiao Liu⁶  Chao Yang⁶  Bo Wang⁷  Jin Tian⁸  Liqun Wang⁹  Xian Sun⁹  Shulan He⁹  Zhizhong Wang^1,10 

[1] Biobank, Laboratory of Surgery, General Hospital of Ningxia Medical University, Yinchuan, China;Surgical Laboratory, General Hospital of Ningxia Medical University, Yinchuan, China;Biobank, Laboratory of Surgery, General Hospital of Ningxia Medical University, Yinchuan, China;Surgical Laboratory, General Hospital of Ningxia Medical University, Yinchuan, China;College of Clinical Medicine, Ningxia Medical University, Yinchuan, China;Biobank, Laboratory of Surgery, General Hospital of Ningxia Medical University, Yinchuan, China;Surgical Laboratory, General Hospital of Ningxia Medical University, Yinchuan, China;Faculty of Health Sciences, University of Macau, Macau, China;Biobank, Laboratory of Surgery, General Hospital of Ningxia Medical University, Yinchuan, China;Surgical Laboratory, General Hospital of Ningxia Medical University, Yinchuan, China;School of Public Health at Guangdong Medical University, Dongguan, China;Center of Laboratory Medicine, General Hospital of Ningxia Medical University, Yinchuan, China;College of Clinical Medicine, Ningxia Medical University, Yinchuan, China;Department of Nursing, General Hospital of Ningxia Medical University, Yinchuan, China;Department of Ultrasound, General Hospital of Ningxia Medical University, Yinchuan, China;School of Public Health and Management, Ningxia Medical University, Yinchuan, China;School of Public Health and Management, Ningxia Medical University, Yinchuan, China;School of Public Health at Guangdong Medical University, Dongguan, China;

关键词: urbanization;    chronic diseases;    gut microbiota;    epidemiological investigation;    microbiome;   

DOI  :  10.3389/fcimb.2021.707402

来源: Frontiers

【 摘 要 】

The continuous development of urbanization has dramatically changed people’s living environment and lifestyle, accompanied by the increased prevalence of chronic diseases. However, there is little research on the effect of urbanization on gut microbiome in residents. Here we investigated the relation between living environment and gut microbiota in a homogenous population along an urban-rural gradient in Ningxia China. According to the degree of urbanization, the population is divided into four groups: mountainous rural (MR) represents non-urbanized areas, mountainous urban (MU) and plain rural (PR) represent preliminary urbanization, and plain urban (PU) is a representative of complete urbanization. Studies have found that with the deepening of urbanization, the prevalence of chronic diseases, such as diabetes, dyslipidemia, fatty liver, gallstones, and renal cysts, have gradually increased. The intestinal richness and diversity of the microbial community were significantly reduced in the PR and the PU groups compared with the MR and the MU groups. Based on linear discriminant analysis selection, the significantly enriched genera Faecalibacterium, Prevotella, and Pseudobutyrivibrio in the MR group gradually decreased in the MU, the PR, and the PU groups. Effect size results revealed that both residence and diet had an effect on intestinal microbiota. Our results suggested that the disparate patterns of gut microbiota composition were revealed at different levels of urbanization, providing an opportunity to understand the pathogenesis of chronic diseases and the contribution of the “rural microbiome” in potential protection against the occurrence of chronic diseases.

【 授权许可】

CC BY