Stage-Dependent Impact of RIPK1 Inhibition on Atherogenesis: Dual Effects on Inflammation and Foam Cell Dynamics

Frontiers in Cardiovascular Medicine

John Bertin¹  Michael Reilly¹  Jean-Luc Tran¹  Brad Geddes¹  Yuze Zhang²  Miao Wang²  Zekun Peng²  Haojie Rao²  Yonghu Huang²  Huihui Li²  Qing Wan²  Hong Chen²  Guoli Yang² 

[1] Innate Immunity Research Unit, GlaxoSmithKline, Collegeville, PA, United States;State Key Laboratory of Cardiovascular Disease and Clinical Pharmacology Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;

关键词: atherosclerosis;    RIPK1;    foam cells;    macrophages;    inflammation;    reverse cholesterol transport;    cell death;   

DOI  :  10.3389/fcvm.2021.715337

来源: Frontiers

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