Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness

Virulence

Sujit Pujhari¹  Jason L Rasgon¹ 

[1] Department of Entomology, The Center for Infectious Disease Dynamics, and the Huck Institutes of the Life Science;

关键词: SARS-CoV-2;    respiratory infectious diseases;    pluripotent stem cell;    animal model;   

DOI  :  10.1080/21505594.2020.1763637

来源: Taylor & Francis

【 摘 要 】

Lack of an appropriate animal model to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for COVID-19 pandemic disease, represents a significant hurdle in the process of understanding disease biology and evaluating therapeutic and preventive candidates. It is time for public health agencies to revisit regulation on transplantation of human pluripotent stem cells for the possibility of the development of a humanized mice model with a humanized lung.

【 授权许可】

CC BY