The two-component signal transduction system and its regulation in Candida albicans

Virulence

Biao Ren¹  Biaoyou Liao²  Xingchen Ye²  Xuedong Zhou³  Yujie Zhou³  Lei Cheng³  Xi Chen³ 

[1] Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Chin;State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases& West China School of Stomatology, Sichuan University, Chengdu, Chin;State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases& West China School of Stomatology, Sichuan University, Chengdu, Chin;Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Chin;

关键词: Candida albicans;    Phosphorelay;    Histidine protein kinase;    Response regulator;    Two-component systems;   

DOI  :  10.1080/21505594.2021.1949883

来源: Taylor & Francis

【 摘 要 】

Candida albicans, which can cause superficial and life-threatening systemic infections, is the most common opportunistic fungal pathogen in the human microbiome. The two-component system is one of the most important C. albicans signal transduction pathways, regulating the response to oxidative and osmotic stresses, adhesion, morphogenesis, cell wall synthesis, virulence, drug resistance, and the host–pathogen interactions. Notably, some components of this signaling pathway have not been found in the human genome, indicating that the two-component system of C. albicans can be a potential target for new antifungal agents. Here, we summarize the composition, signal transduction, and regulation of the two-component system of C. albicans to emphasize its essential roles in the pathogenesis of C. albicans and the new therapeutic target for antifungal drugs.

【 授权许可】

CC BY