A pan-cancer analysis revealed the role of the SLC16 family in cancer

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Yiming Hu¹  Jiaheng Xie²  Zetian Gong²  Rui Wu³  Liang Chen⁴  Yetao Xu⁵  Jiangning Zhao⁶  Dan Wu⁷  Jun Li⁸ 

[1] College of Pharmacy, Jiangsu Ocean University, Lianyungang, Jiangsu, Chin;Department of Burn and Plastic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, Chin;Department of Digestive Endoscopy, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, Chin;Department of General Surgery, Fuyang Hospital Affiliated to Anhui Medical University, Fuyang, Anhui, Chin;Department of Obstetrics and Gynecology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, Chin;Department of Obstetrics and Gynecology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, Chin;Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, Chin;Department of Thoracic Surgery, The First Affiliated Hospital to Nanjing Medical University, Nanjing, Jiangsu, Chin;

关键词: SLC;    transporter;    cancer;    immunology;    bioinformatics;   

DOI  :  10.1080/19336950.2021.1965422

来源: Taylor & Francis

【 摘 要 】

Cancer is one of the serious diseases that endanger human health and bring a heavy burden to world economic development. Although the current targeted therapy and immunotherapy have achieved initial results, the emergence of drug resistance shows that the existing research is far from enough. In recent years, the tumor microenvironment has been found to be an important condition for tumor development and has profound research value. The SLC16 family is a group of monocarboxylic acid transporters involved in cancer metabolism and the formation of the tumor microenvironment. However, there have been no generalized cancer studies in the SLC16 family. In this study, we conducted a pan-cancer analysis of the SLC16 family. The results showed that multiple members of the SLC16 family could be used as prognostic indicators for many tumors, and were associated with immune invasion and tumor stem cells. Therefore, the SLC16 family has extensive exploration value in the future.

【 授权许可】

CC BY