Amaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients*

Pharmaceutical Biology

Maki Sato¹  Magdalena Roszak²  Małgorzata Włochal³  Aldona Juchacz³  Marian Grzymisławski³  Alina Kanikowska³  Agnieszka Zawada³  Rafał Rutkowski⁴  Dominika Kanikowska⁴  Andrzej Bręborowicz⁴  Janusz Witowski⁴  Zofia Orzechowska⁴ 

[1] Departament of Physiology, Aichi Medical University, Nagakute, Japa;Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznań, Poland;Department of Internal Diseases, Metabolism and Nutrition, Poznań University of Medical Science, Poznań, Poland;Department of Pathophysiology, Poznań University of Medical Sciences, Poznań, Poland;

关键词: Neutrophil oxidative burst;    obesity;    plant oil;   

DOI  :  10.1080/13880209.2019.1569696

来源: Taylor & Francis

【 摘 要 】

Context: Amaranth and canola oils have been used traditionally. Amaranth has been identified as being of interest because of its outstanding nutritive value. Amaranth oil is a rich source of highly unsaturated fats and so could be a valuable dietary alternative for individuals affected with obesity. Reactive oxygen species (ROS) are postulated to be involved in systemic inflammation and oxidative stress. Activated polymorphonuclear neutrophils (PMNs) generate high amounts of reactive oxygen species.Objective: Our study investigates the impact of amaranth and canola oils supplementation on oxidative metabolism in patients with obesity. We hypothesized that, due to its lipid-lowering and antioxidant properties, amaranth and canola oil would protect against oxidative stress.Materials and methods: We tested 19 obese patients [body mass index (BMI) = 41.1 ± 7.8 kg/m2, (mean ± SD)]. The protocol consisted of two stages: a run-in phase of 2 weeks and an experimental stage – canola or amaranth oil supplementation (20 mL/d) with calorie restriction diet for 3 weeks. The neutrophil oxidative burst was expressed by fluorescence intensity (IF).Results: The oxidative burst had increased significantly at the end of treatment in both groups IF: (21.4 ± 11.15 vs. 35.9 ± 20.3; mean ± SD) p < 0.05. The levels of IF were significantly higher in neutrophils of patients who received canola oil (41.05 ± 25.3) compared to those who received amaranth oil (28.4 ± 11.8) p < 0.05.Conclusions: Canola oil exerts possible effects on oxidative burst activity in neutrophils in vivo conditions.

【 授权许可】

CC BY