Experimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels

Advances in Physics: X

Joao Luis Carvalho-de-Souza¹  C. A. Z. Bassetto²  Francisco Bezanilla³  Anna Moroni⁴  Andrea Saponaro⁴  Fabio Franciolini⁵  Luigi Catacuzzeno⁵  Oliver Rauh⁶  Gerhard Thiel⁶  Indra Schroeder⁷ 

[1]Department of Anesthesiology, University of Arizona, Tucson AZ, United State

[2]Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago IL, United State

[3]Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago IL, United State

[4]Centro Interdisciplinario De Neurociencias De Valparaíso, Universidad De Valparaíso, Valparaíso, Chil

[5]Department of Biosciences, University of Milan, Milan Ital

[6]Department of Chemistry, Biology and Biotechnology, University of Perugia, Ital

[7]Plant Membrane Biophysics, Technische Universität Darmstadt, Darmstadt, German

[8]Plant Membrane Biophysics, Technische Universität Darmstadt, Darmstadt, German

[9]Physiology II, University Hospital Jena, Friedrich Schiller University Jena, Jena, German

关键词: K channel;    gating;    voltage sensor;    selectivity filter;    intramolecular communication;   

DOI  :  10.1080/23746149.2021.1978317

来源: Taylor & Francis

【 摘 要 】

Biological ion channels precisely control the flow of ions across membranes in response to a range of physical and chemical stimuli. With their ability of transporting ions in a highly selective manner and of integrating regulatory cues, they are a source of inspiration for the construction of solid-state nanopores as sensors or switches for practical applications. Here, we summarize recent advancements in understanding the mechanisms of ion permeation and gating in channel proteins with a focus on the elementary steps of ion transport through the pore and on non-canonical modes of intramolecular communication between peripheral sensory domains and the central channel pore.

【 授权许可】

CC BY