Green synthesis of nickel nanoparticles using Fumaria officinalis as a novel chemotherapeutic drug for the treatment of ovarian cancer

Journal of Experimental Nanoscience

Chunxia Zhu¹  Rongkai Xie²  Yan Huang²  Ming Ni³ 

[1] Dapartment of Gynecology, Xianning Central Hospital (The first Affiliated Hospital of Hubei University of Science and Technology), Xianning, Hubei, Chin;Department of Obstetrics and Gynecology, Chongqing Xinqiao Hospital, Second Affiliated Hospital of Army Medical University, Chongqing, Chin;Department of Obstetrics and Gynecology, Wuhan Hanyang hospital, Wuhan, Chin;

关键词: Green synthesis;    chemical characterization;    nickel nanoparticles;    anti-ovarian cancer;    antioxidant;   

DOI  :  10.1080/17458080.2021.1975037

来源: Taylor & Francis

【 摘 要 】

In the present study, nickel nanoparticles were green-synthesized using the aqueous extract of Fumaria officinalis. The synthesized NiNPs@F. officinalis were characterized by analytical techniques including EDX, FE-SEM, XRD, UV-Vis., and FT-IR. The antioxidant and anti-ovarian cancer activity of NiNPs@F. officinalis was evaluated. The nanoparticles were formed in a spherical shape in the range of 16.85 to 49.04 nm for the particle size. In the antioxidant test, the IC50 of F. officinalis, NiNPs@F. officinalis, and BHT against DPPH free radicals were 253, 145, and 107 µg/mL, respectively. In the cellular and molecular part of the recent study, the treated cells with NiNPs@F. officinalis were assessed by MTT assay for 48 h about the cytotoxicity and anti-human ovarian cancer properties on normal (HUVEC) and ovarian cancer cell lines i.e. PA-1, Caov-3, SW-626, and SK-OV-3. The viability of malignant ovarian cell line reduced dose-dependently in the presence of NiNPs@F. officinalis. The IC50 of NiNPs@F. officinalis were 375, 225, 246, and 279 µg/mL against PA-1, Caov-3, SW-626, and SK-OV-3 cell lines, respectively. After the clinical study, nickel nanoparticles containing F. officinalis leaf aqueous extract may be used to formulate a new chemotherapeutic drug or supplement to treat several types of human ovarian cancer.

【 授权许可】

CC BY