Biophysical comparison of diphtheria and tetanus toxins with the formaldehyde-detoxified toxoids, the main components of diphtheria and tetanus vaccines

Virulence

Jesper W. Petersen¹  Ole Østergaard²  Morten J. Bjerrum³  Husam Alsarraf⁴  Emil Dedic⁴  René Jørgensen⁴  Max Per Kristensen⁵ 

[1] Bacterial Vaccine Department, Statens Serum Institut, Copenhagen S., Denmar;Department of Autoimmunology, Statens Serum Institut, Copenhagen S., Denmar;Department of Chemistry, University of Copenhagen, Copenhagen Ø., Denmar;Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen S., Denmar;Vaccine Development Department, Statens Serum Institut, Copenhagen S., Denmar;

关键词: circular dichroism;    differential scanning fluorimetry;    diphtheria;    MALDI-TOF mass spectrometry;    small-angle X-ray scattering;    tetanus;    toxin;    toxoid;    vaccine;   

DOI  :  10.1080/21505594.2017.1321726

来源: Taylor & Francis

【 授权许可】

Unknown