Emerging Advances of Non-coding RNAs and Competitive Endogenous RNA Regulatory Networks in Asthma

Bioengineered

Xiaoxu Wang¹  Jingjing Liu¹  Hui Chen¹  Fengxia Liu²  Xinyi Yan³  Linlin Gai³  Zhiliang Guo⁴ 

[1] Clinical Medicine College, Weifang Medical University, Weifang Chin;Department of Allergy, The First Affiliated Hospital of Weifang Medical University/ Weifang People’s Hospital, Weifang Chin;Department of Allergy, The First Affiliated Hospital of Weifang Medical University/ Weifang People’s Hospital, Weifang Chin;Department of Central Laboratory, The First Affiliated Hospital of Weifang Medical University/Weifang People’s Hospital, Weifang Chin;Department of Spine Surgery, The 80th Group Army Hospital of Chinese PLA, Weifang Chin;

关键词: Asthma;    non-coding RNAs;    competing endogenous RNAs;    pathogenesis;    biomarker;   

DOI  :  10.1080/21655979.2021.1981796

来源: Taylor & Francis

【 摘 要 】

Asthma is a chronic inflammatory disease characterized by airway remodeling and bronchial hyperresponsiveness. A variety of effector cells and cytokines jointly stimulate the occurrence of inflammatory response in asthma. Although the pathogenesis of asthma is not entirely clear, the possible roles of non-coding RNAs (ncRNAs) have been recently demonstrated. NcRNAs are non-protein-coding RNA molecules, such as circular RNAs (circRNAs), long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), which are involved in the regulation of a variety of biological processes. Mounting studies have shown that ncRNAs play pivotal roles in the occurrence and progression of asthma via competing endogenous RNA (ceRNA) regulatory networks. However, the specific mechanism and clinical application of ncRNAs and ceRNA regulatory networks in asthma have not been fully elucidated, which are worthy of further investigation. This paper comprehensively summarized the current progress on the roles of miRNAs, lncRNAs, circRNAs, and ceRNA regulatory networks in asthma, which can provide a better understanding for the disease pathogenesis and is helpful for identifying novel biomarkers for asthma.

【 授权许可】

CC BY