A comprehensive study of the basic formulation of supersaturated self-nanoemulsifying drug delivery systems (SNEDDS) of albendazolum

Drug Delivery

Hani Alothaid¹  Mohammad Gayoor Khan²  Umama Yezdani³  Mahmoud M. Habibullah⁴  Alaa Alhazmi⁴  Mohammed S. Aldughaim⁵  Azeez Oriyomi Yusuf⁶ 

[1] Department of Basic Sciences, Faculty of Applied Medical Sciences, Al Baha University, Al-Baha, Saudi Arabi;Department of Pharmacovigilance, UCB, Bioclinica, Mysore, Indi;Department of Pharmacy Practice, MRM College of Pharmacy, Hyderabad, Indi;Medical Laboratory Technology Department, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabi;SMIRES for Consultation in Specialized Medical Laboratories, Jazan University, Jazan, Saudi Arabi;Research Center, King Fahad Medical City, Riyadh, Saudi Arabi;School of Biotechnology, Dublin City University, Dublin, Irelan;

关键词: Nanoemulsifying drug delivery system;    albendazole;    SNEDDS;    S-SNEDDS;    SS-SNEDDS;    microcrystalline;   

DOI  :  10.1080/10717544.2021.1986601

来源: Taylor & Francis

【 摘 要 】

Albendazolum (ABZ) is a BCS class II drug. It has challenging biopharmaceutical properties, which include poor solubility and dissolution rate. These properties have laid the ground for developing a supersaturated self-nanoemulsifying drug delivery system (S-SNEDDS) to form oil-in-water nanoemulsion in situ to improve the oral bioavailability of ABZ. Based on the ABZ solubility, emulsifying ability, and stability after dispersion in an aqueous phase, an optimal self-nanoemulsifying drug delivery system (SNEDDS) consisting of oleic acid, Tween® 20, and PEG 600 (X:Y:Z, w/w) was identified, having 10% (w/w) hydroxypropyl methylcellulose (HPMC) E15 lv as its precipitation inhibitor. The optimized system possessed a small mean globule size value (89.2 nm), good dispersion properties (polydispersity index (PDI): 0.278), and preserved the supersaturated state of ABZ. S-SNEDDS was transformed into solid supersaturated self-nanoemulsifying drug delivery systems (SS-SNEDDS) using microcrystalline cellulose as a solid material. The developed S-SNEDDS were characterized for globule size, pH, turbidity, differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and flow properties. The data obtained from the results suggest that this S-SNEDDS formulation can enhance the solubility and oral bioavailability of ABZ for appropriate clinical application.

【 授权许可】

CC BY