PKM2 promotes angiotensin‐II‐induced cardiac remodelling by activating TGF‐β/Smad2/3 and Jak2/Stat3 pathways through oxidative stress

Journal of Cellular and Molecular Medicine

Yan Meng¹  Xiyu Zhang¹  Cuiting Zheng¹  Zhenqiang Gao¹  Chen Chen²  Lingling Wang³  Yuanyuan Zheng⁴ 

[1] Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, Beijing Lab for Cardiovascular Precision Medicine, Department of Pathology, Capital Medical University, Beijing, China;China‐America Institute of Neuroscience, Beijing Luhe Hospital, Capital Medical University, Beijing, China;Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China;Department of Pharmacology, Capital Medical University, Beijing, China;

关键词: Ang II;    cardiac remodelling;    oxidative stress;    PKM2;    shikonin;   

DOI  :  10.1111/jcmm.17007

来源: Wiley

【 授权许可】

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