Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration

Aging Cell

Zahra Ashkavand¹  Shaarika Sarasija¹  Kerry C. Ryan¹  Rohan Samarakoon¹  Kenneth R. Norman¹  Jocelyn T. Laboy¹ 

[1] Department of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, New York, USA;

关键词: aging;    Alzheimer;    Caenorhabditis elegans;    calcium;    mitochondria;    mTORC1;    presenilin;   

DOI  :  10.1111/acel.13472

来源: Wiley

【 授权许可】

CC BY