Inhibition of the amino‐acid transporter LAT1 demonstrates anti‐neoplastic activity in medulloblastoma

Journal of Cellular and Molecular Medicine

Vincent Picco¹  Yann Cormerais¹  Sandy Giuliano¹  Marina Pagnuzzi‐Boncompagni¹  Gilles Pagès²  Jacques Pouysségur²  Sandra Schrötter³  Hitoshi Endou⁴  Eric Tambutté⁵  Michael F. Wempe⁶ 

[1] Biomedical Department, Centre Scientifique de Monaco, Monaco, Principality of Monaco;Biomedical Department, Centre Scientifique de Monaco, Monaco, Principality of Monaco;Institute for Research on Cancer and Aging of Nice (IRCAN), CNRS UMR 7284, INSERM U1081, Centre Antoine Lacassagne, University of Cote d’Azur, Nice, France;Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts;J‐Pharma, Co. Ltd., Yokohama, Japan;Marine Biology Department, Centre Scientifique de Monaco, Monaco, Principality of Monaco;School of Pharmacy, Anschutz Medical Campus, University of Colorado Denver, Aurora, Colorado;

关键词: amino acid transport;    ATF4;    GCN2;    medulloblastoma;    mTORC1;   

DOI  :  10.1111/jcmm.14176

来源: Wiley

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