Histone deacetylase inhibitor LMK235 attenuates vascular constriction and aortic remodelling in hypertension

Journal of Cellular and Molecular Medicine

Seung‐Jung Kee¹  Hae Jin Kee²  Yuhee Ryu²  Myung Ho Jeong²  Gwi Ran Kim²  Sin Young Choi³  Simei Sun⁴  Marc Pflieger⁵  Thomas Kurz⁵  Matthias U. Kassack⁵  Young Mi Seok⁶ 

[1] Department of Laboratory Medicine, Chonnam National University, Medical School and Hospital, Gwangju, Republic of Korea;Heart Research Center of Chonnam National University Hospital, Gwangju, Republic of Korea;Hypertension Heart Failure Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea;Heart Research Center of Chonnam National University Hospital, Gwangju, Republic of Korea;Hypertension Heart Failure Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea;Molecular Medicine, Brain Korea 21 PLUS, Chonnam National University Graduate School, Gwangju, Republic of Korea;Heart Research Center of Chonnam National University Hospital, Gwangju, Republic of Korea;Hypertension Heart Failure Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea;Molecular Medicine, Brain Korea 21 PLUS, Chonnam National University Graduate School, Gwangju, Republic of Korea;Zhoushan Hospital, Zhejiang University School of Medicine, Zhoushan, Zhejiang, China;Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany;National Development Institute of Korean Medicine, Gyeongsan‐si, Gyeongsangbuk‐do, Republic of Korea;

关键词: calcium calmodulin‐dependent protein kinase II;    HDAC5;    hypertension;    vascular hyperplasia;    vasoconstriction;   

DOI  :  10.1111/jcmm.14188

来源: Wiley

【 授权许可】

CC BY